Aims Because low-grade inflammation may play a role in the pathogenesis of coronary heart
disease (CHD), and pro-inflammatory cytokines govern inflammatory cascades, this study …

The occurrence of thyroid diseases is determined by interplay between genetic and
environmental factors. The major environmental factor that determines goiter prevalence is …

Background: Iodine intake is often measured by a surrogate measure, namely urine iodine
excretion as almost all ingested iodine is excreted in the urine. However, the methods for …

We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we
report the human gut microbial composition in a population sample of 123 non-obese and …

Genome-wide association (GWA) studies have identified multiple loci at which common
variants modestly but reproducibly influence risk of type 2 diabetes (T2D),,,,,,,,,,. Established …

By combining genome-wide association data from 8,130 individuals with type 2 diabetes
(T2D) and 38,987 controls of European descent and following up previously unidentified …

In recent years, several associations between common chronic human disorders and altered
gut microbiome composition and function have been reported,. In most of these reports …

Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2
diabetes. Here we show how the human gut microbiome impacts the serum metabolome …

We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130
European-descent individuals (9% cases), after imputation to high-density reference panels …

To study the effect of host genetics on gut microbiome composition, the MiBioGen
consortium curated and analyzed genome-wide genotypes and 16S fecal microbiome data …