Objective To develop new classification criteria for systemic lupus erythematosus (SLE)
jointly supported by the European League Against Rheumatism (EULAR) and the American …

Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and
chloroquine in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus …

Plasma cells provide humoral immunity. They have traditionally been viewed mainly as short-
lived end-stage products of B-cell differentiation that deserve little interest. This view is …

Objectives To develop recommendations for the management of adult and paediatric lupus
nephritis (LN). Methods The available evidence was systematically reviewed using the …

B lymphocytes have critical roles as positive and negative regulators of immunity. Their
inhibitory function has been associated primarily with interleukin 10 (IL-10) because B-cell …

Objective To develop new antiphospholipid syndrome (APS) classification criteria with high
specificity for use in observational studies and trials, jointly supported by the American …

These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

The objective was to develop evidence-based recommendations for the management of
antiphospholipid syndrome (APS) in adults. Based on evidence from a systematic literature …

In patients with active systemic lupus erythematosus (SLE), a marked B lymphocytopenia
was identified that affected CD19+/CD27− naive B cells more than CD19+/CD27+ memory B …

The principle of treating-to-target has been successfully applied to many diseases outside
rheumatology and more recently to rheumatoid arthritis. Identifying appropriate therapeutic …