BACKGROUND Despite many notable successes in prevention and control, infectious
diseases remain an enormous threat to human and animal health. The ecological and …

Background Why some individuals develop AIDS rapidly whereas others remain healthy
without treatment for many years remains a central question of HIV research. Of the …

The realisation of human potential for development requires age-specific investment
throughout the 8000 days of childhood and adolescence. Focus on the first 1000 days is an …

Governments will not be able to minimise both deaths from coronavirus disease 2019
(COVID19) and the economic impact of viral spread. Keeping mortality as low as possible …

A novel influenza A (H1N1) virus has spread rapidly across the globe. Judging its pandemic
potential is difficult with limited data, but nevertheless essential to inform appropriate health …

Background. The epidemiological impact of public health interventions targeted at reducing
transmission of human immunodeficiency virus type 1 (HIV-1) during early or late-stage …

Background Over the past decade malaria intervention coverage has been scaled up across
Africa. However, it remains unclear what overall reduction in transmission is achievable …

The natural course of HIV-1 infection is characterized by a high degree of heterogeneity in
viral load, not just within patients over time, but also between patients, especially during the …

Objective Contact tracing is a central public health response to infectious disease outbreaks,
especially in the early stages of an outbreak when specific treatments are limited …

A key question in contingency planning for a possible influenza pandemic is the value of
restricting international travel to and from affected countries or regions, or imposing entry or …