User profiles for "author:Spiros Denaxas"
Spiros DenaxasProfessor of Biomedical Informatics, University College London Verified email at ucl.ac.uk Cited by 14033 |
Reporting guideline for the early stage clinical evaluation of decision support systems driven by artificial intelligence: DECIDE-AI
A growing number of artificial intelligence (AI)-based clinical decision support systems are
showing promising performance in preclinical, in silico, evaluation, but few have yet …
showing promising performance in preclinical, in silico, evaluation, but few have yet …
Big data from electronic health records for early and late translational cardiovascular research: challenges and potential
Aims Cohorts of millions of people's health records, whole genome sequencing, imaging,
sensor, societal and publicly available data present a rapidly expanding digital trace of …
sensor, societal and publicly available data present a rapidly expanding digital trace of …
Critical appraisal of artificial intelligence-based prediction models for cardiovascular disease
The medical field has seen a rapid increase in the development of artificial intelligence (AI)-
based prediction models. With the introduction of such AI-based prediction model tools and …
based prediction models. With the introduction of such AI-based prediction model tools and …
[HTML][HTML] Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1· 25 million people
Background The associations of blood pressure with the different manifestations of incident
cardiovascular disease in a contemporary population have not been compared. In this study …
cardiovascular disease in a contemporary population have not been compared. In this study …
[HTML][HTML] Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1· 9 million people
AD Shah, C Langenberg, E Rapsomaniki… - The lancet Diabetes & …, 2015 - thelancet.com
Background The contemporary associations of type 2 diabetes with a wide range of incident
cardiovascular diseases have not been compared. We aimed to study associations between …
cardiovascular diseases have not been compared. We aimed to study associations between …
[HTML][HTML] Estimating excess 1-year mortality associated with the COVID-19 pandemic according to underlying conditions and age: a population-based cohort study
A Banerjee, L Pasea, S Harris, A Gonzalez-Izquierdo… - The Lancet, 2020 - thelancet.com
Background The medical, societal, and economic impact of the coronavirus disease 2019
(COVID-19) pandemic has unknown effects on overall population mortality. Previous models …
(COVID-19) pandemic has unknown effects on overall population mortality. Previous models …
[HTML][HTML] Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion
of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide …
of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide …
Association of COVID-19 with major arterial and venous thrombotic diseases: a population-wide cohort study of 48 million adults in England and Wales
Background: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
induces a prothrombotic state, but long-term effects of COVID-19 on incidence of vascular …
induces a prothrombotic state, but long-term effects of COVID-19 on incidence of vascular …
Completeness and diagnostic validity of recording acute myocardial infarction events in primary care, hospital care, disease registry, and national mortality records …
Objective To determine the completeness and diagnostic validity of myocardial infarction
recording across four national health record sources in primary care, hospital care, a …
recording across four national health record sources in primary care, hospital care, a …
[HTML][HTML] Rare and common genetic determinants of metabolic individuality and their effects on human health
P Surendran, ID Stewart, VPW Au Yeung, M Pietzner… - Nature Medicine, 2022 - nature.com
Garrod's concept of 'chemical individuality'has contributed to comprehension of the
molecular origins of human diseases. Untargeted high-throughput metabolomic …
molecular origins of human diseases. Untargeted high-throughput metabolomic …