User profiles for "author:Spiros Denaxas"

Spiros Denaxas

Professor of Biomedical Informatics, University College London
Verified email at ucl.ac.uk
Cited by 14033

Reporting guideline for the early stage clinical evaluation of decision support systems driven by artificial intelligence: DECIDE-AI

B Vasey, M Nagendran, B Campbell, DA Clifton… - bmj, 2022 - bmj.com
A growing number of artificial intelligence (AI)-based clinical decision support systems are
showing promising performance in preclinical, in silico, evaluation, but few have yet …

Big data from electronic health records for early and late translational cardiovascular research: challenges and potential

H Hemingway, FW Asselbergs, J Danesh… - European heart …, 2018 - academic.oup.com
Aims Cohorts of millions of people's health records, whole genome sequencing, imaging,
sensor, societal and publicly available data present a rapidly expanding digital trace of …

Critical appraisal of artificial intelligence-based prediction models for cardiovascular disease

M Van Smeden, G Heinze, B Van Calster… - European heart …, 2022 - academic.oup.com
The medical field has seen a rapid increase in the development of artificial intelligence (AI)-
based prediction models. With the introduction of such AI-based prediction model tools and …

[HTML][HTML] Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1· 25 million people

E Rapsomaniki, A Timmis, J George… - The Lancet, 2014 - thelancet.com
Background The associations of blood pressure with the different manifestations of incident
cardiovascular disease in a contemporary population have not been compared. In this study …

[HTML][HTML] Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1· 9 million people

AD Shah, C Langenberg, E Rapsomaniki… - The lancet Diabetes & …, 2015 - thelancet.com
Background The contemporary associations of type 2 diabetes with a wide range of incident
cardiovascular diseases have not been compared. We aimed to study associations between …

[HTML][HTML] Estimating excess 1-year mortality associated with the COVID-19 pandemic according to underlying conditions and age: a population-based cohort study

A Banerjee, L Pasea, S Harris, A Gonzalez-Izquierdo… - The Lancet, 2020 - thelancet.com
Background The medical, societal, and economic impact of the coronavirus disease 2019
(COVID-19) pandemic has unknown effects on overall population mortality. Previous models …

[HTML][HTML] Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

S Shah, A Henry, C Roselli, H Lin… - Nature …, 2020 - nature.com
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion
of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide …

Association of COVID-19 with major arterial and venous thrombotic diseases: a population-wide cohort study of 48 million adults in England and Wales

R Knight, V Walker, S Ip, JA Cooper, T Bolton… - Circulation, 2022 - Am Heart Assoc
Background: Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
induces a prothrombotic state, but long-term effects of COVID-19 on incidence of vascular …

Completeness and diagnostic validity of recording acute myocardial infarction events in primary care, hospital care, disease registry, and national mortality records …

E Herrett, AD Shah, R Boggon, S Denaxas, L Smeeth… - Bmj, 2013 - bmj.com
Objective To determine the completeness and diagnostic validity of myocardial infarction
recording across four national health record sources in primary care, hospital care, a …

[HTML][HTML] Rare and common genetic determinants of metabolic individuality and their effects on human health

P Surendran, ID Stewart, VPW Au Yeung, M Pietzner… - Nature Medicine, 2022 - nature.com
Garrod's concept of 'chemical individuality'has contributed to comprehension of the
molecular origins of human diseases. Untargeted high-throughput metabolomic …