Systematic reviews and meta-analyses can provide convincing and reliable evidence
relevant to many aspects of medicine and health care. 1 Their value is especially clear when …

Meta-analysis in the presence of unexplained heterogeneity is frequently undertaken by
using a random-effects model, in which the effects underlying different studies are assumed …

Background: Guidelines advocate changes in fatty acid consumption to promote
cardiovascular health. Purpose: To summarize evidence about associations between fatty …

The extent of heterogeneity in a meta‐analysis partly determines the difficulty in drawing
overall conclusions. This extent may be measured by estimating a between‐study variance …

Appropriate methods for meta‐regression applied to a set of clinical trials, and the limitations
and pitfalls in interpretation, are insufficiently recognized. Here we summarize recent …

Genome‐wide association studies, which typically report regression coefficients
summarizing the associations of many genetic variants with various traits, are potentially a …

Background Overweight and obesity are increasing worldwide. To help assess their
relevance to mortality in different populations we conducted individual-participant data meta …

Background Inflammation is an important feature of atherosclerotic lesions, and increased
production of the acute-phase reactant, C-reactive protein (CRP), is associated with a poor …

Background Low-risk limits recommended for alcohol consumption vary substantially across
different national guidelines. To define thresholds associated with lowest risk for all-cause …

Aims Large randomized trials have shown that beta-blockers reduce mortality and hospital
admissions in patients with heart failure. The effects of beta-blockers in elderly patients with …