The discovery that mammalian cells generate nitric oxide, a gas previously considered to be
merely an atmospheric pollutant, is providing important information about many biologic …

Nitric oxide is an inorganic free radical gas, of formula* N= O (abbreviated as NO). The
discovery in 1987/88 that vascular endothelial cells are able to synthesize NO from L …

Fig. 1.(A) Effect of~“N~ fMA (lO# m~ kg-“, adm~~ j~ tered as a IS-set infusion ivf on btoocl
pressure {BP) and heart rate (HR) in the anesthetized rabbit,(S) Reversal of the effect of L …

Endothelium-derived relaxing factor (EDRF) is a labile humoral agent which mediates the
action of some vasodilators. Nitrovasodi-lators, which may act by releasing nitric oxide (NO) …

Abstract NG monomethyl-L-arginine (L-NMMA), a specific inhibitor of the synthesis of
endothelium-derived nitric oxide (NO), was infused into the brachial arteries of healthy …

A soluble enzyme obtained from rat forebrain catalyzes the NADPH-dependent formation of
nitric oxide (NO) and citrulline from L-arginine. The NO formed stimulates the soluble …

The formation of nitric oxide (NO) from L-arginine by vascular endothelial cells and its
relationship to endothelium-dependent relaxation of vascular rings was studied. The release …

NITRIC oxide (NO) is important in many biological functions1–5. It is generated from L-
arginine by the enzyme NO synthase (NOS). The cytokine-inducible NOS (iNOS) is activated …

Nitric oxide was found to trigger mitochondrial biogenesis in cells as diverse as brown
adipocytes and 3T3-L1, U937, and HeLa cells. This effect of nitric oxide was dependent on …

We have examined the effects of pregnancy and sex hormones on calcium-dependent and
calcium-independent nitric oxide synthases (NOSs) in the guinea pig. Pregnancy (near term) …