User profiles for "author:SJ Fleming"
Stephen J. FlemingResearch Scientist, Broad Institute Verified email at broadinstitute.org Cited by 1527 |
[HTML][HTML] COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
COVID-19, which is caused by SARS-CoV-2, can result in acute respiratory distress
syndrome and multiple organ failure,,–, but little is known about its pathophysiology. Here …
syndrome and multiple organ failure,,–, but little is known about its pathophysiology. Here …
The use of vaccines in renal failure
DW Johnson, SJ Fleming - Clinical pharmacokinetics, 1992 - Springer
Renal insufficiency is characterised by impaired host defences, which are compromised
further by each of the 3 modes of renal replacement—haemodialysis, continuous ambulatory …
further by each of the 3 modes of renal replacement—haemodialysis, continuous ambulatory …
Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy
Heart failure encompasses a heterogeneous set of clinical features that converge on
impaired cardiac contractile function, and presents a growing public health concern …
impaired cardiac contractile function, and presents a growing public health concern …
Transcriptional and cellular diversity of the human heart
Background: The human heart requires a complex ensemble of specialized cell types to
perform its essential function. A greater knowledge of the intricate cellular milieu of the heart …
perform its essential function. A greater knowledge of the intricate cellular milieu of the heart …
Genome-wide association study of glioma and meta-analysis
…, M Braganza, T Carreon, M Feychting, SJ Fleming… - Human genetics, 2012 - Springer
Gliomas account for approximately 80% of all primary malignant brain tumors and, despite
improvements in clinical care over the last 20 years, remain among the most lethal tumors …
improvements in clinical care over the last 20 years, remain among the most lethal tumors …
Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors
…, K Gousias, J Schramm, MJ Schoemaker, SJ Fleming… - Nature …, 2017 - nature.com
Genome-wide association studies (GWAS) have transformed our understanding of glioma
susceptibility, but individual studies have had limited power to identify risk loci. We …
susceptibility, but individual studies have had limited power to identify risk loci. We …
[BOOK][B] The origins and ancient history of wine: food and nutrition in history and antropology
PE McGovern, SJ Fleming, SH Katz - 2003 - books.google.com
This volume presents contemporary evidence scientific, archaeological, botanical, textual,
and historical for major revisions in our understanding of winemaking in antiquity. Among …
and historical for major revisions in our understanding of winemaking in antiquity. Among …
Deep learning enables genetic analysis of the human thoracic aorta
Enlargement or aneurysm of the aorta predisposes to dissection, an important cause of
sudden death. We trained a deep learning model to evaluate the dimensions of the …
sudden death. We trained a deep learning model to evaluate the dimensions of the …
[PDF][PDF] CellBender remove-background: a deep generative model for unsupervised removal of background noise from scRNA-seq datasets
Droplet-based scRNA-seq assays are known to produce a significant amount of background
RNA counts, the hallmark of which is non-zero transcript counts in presumably empty …
RNA counts, the hallmark of which is non-zero transcript counts in presumably empty …
[HTML][HTML] Genome-wide association study identifies multiple susceptibility loci for glioma
…, J Schramm, MJ Schoemaker, SJ Fleming… - Nature …, 2015 - nature.com
Previous genome-wide association studies (GWASs) have shown that common genetic
variation contributes to the heritable risk of glioma. To identify new glioma susceptibility loci …
variation contributes to the heritable risk of glioma. To identify new glioma susceptibility loci …