User profiles for "author:Paul Clarke"

Paul Clarke

- Verified email at icr.ac.uk - Cited by 18863

Paul Clarke

- Verified email at mcgill.ca - Cited by 12277

Paul R Clarke

- Verified email at uq.edu.au - Cited by 9187

[HTML][HTML] Discovery of small molecule cancer drugs: successes, challenges and opportunities

S Hoelder, PA Clarke, P Workman - Molecular oncology, 2012 - Elsevier
The discovery and development of small molecule cancer drugs has been revolutionised
over the last decade. Most notably, we have moved from a one-size-fits-all approach that …

International Union of Pharmacology. XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits

RJ Lukas, JP Changeux, N le Novère… - Pharmacological …, 1999 - ASPET
Nicotinic acetylcholine receptors (nACh receptors2) in jawed vertebrates are prototypical
members of the multisubunit, neurotransmitter-gated superfamily of ion channels (ionotropic …

Spatial and temporal coordination of mitosis by Ran GTPase

PR Clarke, C Zhang - Nature reviews Molecular cell biology, 2008 - nature.com
Abstract The small nuclear GTPase Ran controls the directionality of macromolecular
transport between the nucleus and the cytoplasm. Ran also has important roles during …

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

G Vlachogiannis, S Hedayat, A Vatsiou, Y Jamin… - Science, 2018 - science.org
Patient-derived organoids (PDOs) have recently emerged as robust preclinical models;
however, their potential to predict clinical outcomes in patients has remained unclear. We …

The Identification of 2-(1H-Indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a Potent, Selective …

AJ Folkes, K Ahmadi, WK Alderton, S Alix… - Journal of medicinal …, 2008 - ACS Publications
Phosphatidylinositol-3-kinase (PI3K) is an important target in cancer due to the deregulation
of the PI3K/Akt signaling pathway in a wide variety of tumors. A series of thieno [3, 2-d] …

The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine

WA Corrigall, KBJ Franklin, KM Coen, PBS Clarke - Psychopharmacology, 1992 - Springer
Rats were trained to self-administer nicotine on a fixed-ratio schedule of reinforcement.
Infusion of the nicotinic antagonist chlorisondamine into the cerebral ventricles produced a …

Kirsten ras mutations in patients with colorectal cancer: the multicenter “RASCAL” study

HJN Andreyev, AR Norman, PA Clarke… - JNCI: Journal of the …, 1998 - academic.oup.com
Abstract Background: Kirsten ras (Ki-ras) gene mutations occur early in the progression of
colorectal adenoma to carcinoma. The aim of this collaborative study was to clarify the …

Phosphorylation and activation of human cdc25‐C by cdc2‐‐cyclin B and its involvement in the self‐amplification of MPF at mitosis.

I Hoffmann, PR Clarke, MJ Marcote, E Karsenti… - The EMBO …, 1993 - embopress.org
We have investigated the mechanisms responsible for the sudden activation of the cdc2‐
cyclin B protein kinase before mitosis. It has been found previously that cdc25 is the tyrosine …

[HTML][HTML] Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1

B Panaretou, G Siligardi, P Meyer, A Maloney… - Molecular cell, 2002 - cell.com
Client protein activation by Hsp90 involves a plethora of cochaperones whose roles are
poorly defined. A ubiquitous family of stress-regulated proteins have been identified (Aha1 …

Autoradiographic evidence for nicotine receptors on nigrostriatal and mesolimbic dopaminergic neurons

PBS Clarke, AGU Pert - Brain research, 1985 - Elsevier
Rats received unilateral injections of 6-hydroxydopamine into the medial forebrain bundle,
resulting in an ipsilateral loss of striatal dopamine and of dopaminergic perikarya. A …