Inability to replicate many results has led to increasing scepticism about the value of simple
association study designs for detection of genetic variants contributing to common complex …

Coronary heart disease rates have been reported in several parts of the world to be
unusually high in people originating from the Indian subcontinent. High coronary disease …

Exploration of the human genome presents new challenges and opportunities for
epidemiological research. Although the case-control design is quicker and cheaper for study …

Lighter variations of pigmentation in humans are associated with diminished number, size,
and density of melanosomes, the pigmented organelles of melanocytes. Here we show that …

The hypothesis that the high mortality from coronary heart disease (CHD) in South Asians
settled overseas compared with other populations is due to metabolic disturbances related …

Uric acid is the end product of purine metabolism in humans and great apes, which have lost
hepatic uricase activity, leading to uniquely high serum uric acid concentrations (200–500 …

Objective: To establish whether fetal growth rate (as distinct from size at birth) is associated
with mortality from ischaemic heart disease. Design: Cohort study based on uniquely …

Effect of Vaccination on Transmission of SARS-CoV-2 | NEJM Skip to main content NEJM
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Objective: To establish whether the relation between size at birth and non-insulin dependent
diabetes is mediated through impaired β cell function or insulin resistance. Design: Cohort …

Ancestry informative markers (AIMs) are genetic loci showing alleles with large frequency
differences between populations. AIMs can be used to estimate biogeographical ancestry at …