Background Information on life expectancy and risk factors for early death among patients
with sickle cell disease (sickle cell anemia, sickle cell-hemoglobin C disease, and the sickle …

Abstract Background and Methods. Acute episodes of pain are the principal symptom of
sickle cell disease, but little is known about the epidemiologic features of these episodes or …

Abstract Background and Methods. Osteonecrosis of the femoral head is an important
complication of sickle cell disease. We studied 2590 patients who were over 5 years of age …

Patients with sickle cell anemia were treated with daily doses of hydroxyurea, to assess
pharmacokinetics, toxicity, and increase in fetal hemoglobin (Hb) production in response to …

The blood in sickle cell anemia has a very low oxygen affinity and, although 2, 3-
diphosphoglycerate (2, 3-DPG) is increased, there is doubt as to whether this is the only …

Abstract Haemoglobin Constant Spring is an unusual variant which comprises only 1–2% of
the total haemoglobin in heterozygotes. It has α-chains which are 172 residues long instead …

The prevalence and incidence of osteonecrosis (ON) of the humeral head in sickle cell
disease was determined by a study of 2524 patients who were entered into a prospective …

The outcome of pregnancy has been analyzed in 72 women with sickle cell anemia (SS)
and 26 women with sickle cell-hemoglobin C disease (SC), part of an unselected population …

In Africa, the β‐globin gene cluster haplotype may be associated with variation of Hb F
levels in subjects with sickle cell anemia (SS). These observations have not yet been …

Red cell survival was estimated in a group of adult sickle cell anaemia patients using the
51Cr technique. Counts of irreversibly sickled cells were performed on thin coverslip …