Background Long working hours might increase the risk of cardiovascular disease, but
prospective evidence is scarce, imprecise, and mostly limited to coronary heart disease. We …

Background Small birth size may be associated with increased risk of cardiovascular
diseases (CVD), whereas large birth size may predict increased risk of obesity and some …

BackgroundAdverse psychosocial working environments characterized by job strain (the
combination of high demands and low control at work) are associated with an increased risk …

Background Published work assessing psychosocial stress (job strain) as a risk factor for
coronary heart disease is inconsistent and subject to publication bias and reverse causation …

Background In 2011, WHO member states signed up to the 25× 25 initiative, a plan to cut
mortality due to non-communicable diseases by 25% by 2025. However, socioeconomic …

Background Little is known about the timing of changes in glucose metabolism before
occurrence of type 2 diabetes. We aimed to characterise trajectories of fasting and postload …

Personality may influence the risk of death, but the evidence remains inconsistent. We
examined associations between personality traits of the five-factor model (extraversion …

Background Although overweight and obesity have been studied in relation to individual
cardiometabolic diseases, their association with risk of cardiometabolic multimorbidity is …

Background Governments need to increase the proportion of the population in work in most
developed countries because of ageing populations. We investigated longitudinally how self …

Background The accumulation of disparate diseases in complex multimorbidity makes
prevention difficult if each disease is targeted separately. We aimed to examine obesity as a …