In the United States in the period 1973–1997, the incidence and mortality due to large bowel
cancer was higher in blacks than in other ethnic groups. The incidence in blacks in the …

Epidemiologic and mechanistic evidence suggests that folate is involved in colorectal
neoplasia. Some polymorphic genes involved in folate metabolism …

Background The rising prevalence of overweight and obesity places a financial burden on
health services and on the wider economy. Health service and societal costs of overweight …

The autosomal dominant syndrome of Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
is due to germline DNA mismatch repair gene mutations in most cases. However, the …

Purpose Preclinical studies have demonstrated that antagonism of ß2-adrenergic signaling
inhibits several pathways necessary for breast tumor progression and metastasis. A series of …

Background Previous studies that showed an association between smoking and
adenocarcinomas of the esophagus and esophagogastric junction were limited in their …

Background Previous studies suggest an association between obesity and oesophageal
(OA) and oesophagogastric junction adenocarcinomas (OGJA). However, these studies …

Objective The COVID-19 pandemic has had a major global impact on endoscopic services.
This reduced capacity, along with public reluctance to undergo endoscopy during the …

Aging is a universal but poorly understood biological process. Free radicals accumulate with
age and have been proposed to be a major cause of aging. We measured genome-wide …

T cell differentiation and repertoire selection depend critically on several distinct thymic
epithelial cell types, whose lineage relationships are unclear. We have investigated these …