User profiles for "author:Leah M Smith"

Leah M. Smith

University of Otago
Verified email at otago.ac.nz
Cited by 174

Projected estimates of cancer in Canada in 2020

DR Brenner, HK Weir, AA Demers, LF Ellison… - Cmaj, 2020 - Can Med Assoc
BACKGROUND: Cancer projections to the current year help in policy development, planning
of programs and allocation of resources. We sought to provide an overview of the expected …

Effect of human papillomavirus (HPV) vaccination on clinical indicators of sexual behaviour among adolescent girls: the Ontario Grade 8 HPV Vaccine Cohort Study

LM Smith, JS Kaufman, EC Strumpf, LE Lévesque - Cmaj, 2015 - Can Med Assoc
Background: Suboptimal human papillomavirus (HPV) vaccine coverage in some
jurisdictions is partly attributed to fears that vaccination may increase risky sexual behaviour …

[PDF][PDF] Type III CRISPR-Cas provides resistance against nucleus-forming jumbo phages via abortive infection

D Mayo-Muñoz, LM Smith, C Garcia-Doval, LM Malone… - Molecular cell, 2022 - cell.com
Bacteria have diverse defenses against phages. In response, jumbo phages evade multiple
DNA-targeting defenses by protecting their DNA inside a nucleus-like structure. We …

SorTn-seq: a high-throughput functional genomics approach to discovering regulators of bacterial gene expression

LM Smith, SA Jackson, PP Gardner, PC Fineran - Nature Protocols, 2021 - nature.com
We recently developed a high-throughput functional genomics approach, named 'SorTn-
seq', to identify factors affecting expression of any gene of interest in bacteria. Our approach …

The early benefits of human papillomavirus vaccination on cervical dysplasia and anogenital warts

LM Smith, EC Strumpf, JS Kaufman, A Lofters… - …, 2015 - publications.aap.org
BACKGROUND: Despite widespread promotion of quadrivalent human papillomavirus
(qHPV) vaccination for young girls, there is limited information on the vaccine's real-world …

The Rcs stress response inversely controls surface and CRISPR–Cas adaptive immunity to discriminate plasmids and phages

LM Smith, SA Jackson, LM Malone, JE Ussher… - Nature …, 2021 - nature.com
Bacteria harbour multiple innate defences and adaptive CRISPR–Cas systems that provide
immunity against bacteriophages and mobile genetic elements. Although some bacteria …

The autoregulator Aca2 mediates anti-CRISPR repression

N Birkholz, RD Fagerlund, LM Smith… - Nucleic acids …, 2019 - academic.oup.com
CRISPR-Cas systems are widespread bacterial adaptive defence mechanisms that provide
protection against bacteriophages. In response, phages have evolved anti-CRISPR proteins …

The burden of cancer attributable to modifiable risk factors in Canada: Methods overview

DR Brenner, CM Friedenreich, Y Ruan, AE Poirier… - Preventive …, 2019 - Elsevier
Up-to-date estimates of current and projected future cancer burden attributable to various
exposures are essential for planning and implementing cancer prevention initiatives. The …

Quadrivalent human papillomavirus vaccination in girls and the risk of autoimmune disorders: the Ontario Grade 8 HPV Vaccine Cohort Study

EY Liu, LM Smith, AK Ellis, H Whitaker, B Law… - Cmaj, 2018 - Can Med Assoc
BACKGROUND: Despite demonstrated effectiveness in real-world settings, concerns persist
regarding the safety of the quadrivalent human papillomavirus (HPV4) vaccine. We sought …

[HTML][HTML] Factors associated with initiation and completion of the quadrivalent human papillomavirus vaccine series in an Ontario cohort of grade 8 girls

LM Smith, P Brassard, JC Kwong, SL Deeks, AK Ellis… - BMC Public Health, 2011 - Springer
Background Although over a hundred million dollars have been invested in offering free
quadrivalent human papillomavirus (HPV) vaccination to young girls in Ontario, there …