Socioeconomic status (SES) has a measurable and significant effect on cardiovascular
health. Biological, behavioral, and psychosocial risk factors prevalent in disadvantaged …

Background and Purpose: Population-wide reductions in cardiovascular disease incidence
and mortality have not been shared equally by African Americans. The burden of …

Objective: The design, overall methods, and major phenotypes for the all-African-American
Jackson Heart Study (JHS) are detailed. Methods: Participants were enrolled from the three …

The genetic architecture of common traits, including the number, frequency, and effect sizes
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …

Myocardial infarction (MI), a leading cause of death around the world, displays a complex
pattern of inheritance,. When MI occurs early in life, genetic inheritance is a major …

Objective: Obesity is a major driver of cardiometabolic risk. Abdominal visceral adipose
tissue (VAT) and sc adipose tissue (SAT) may confer differential metabolic risk profiles. We …

Background Observational and randomized studies designed to compare surgical and
medical therapies in patients with left main coronary artery disease (LMCD) have shown that …

Persistently low white blood cell count (WBC) and neutrophil count is a well-described
phenomenon in persons of African ancestry, whose etiology remains unknown. We recently …

Low-frequency coding DNA sequence variants in the proprotein convertase subtilisin/kexin
type 9 gene (PCSK9) lower plasma low-density lipoprotein cholesterol (LDL-C), protect …

Background Combined severe proximal left anterior descending and proximal left circumflex
coronary artery disease, or left main equivalent (LMEQ) disease, defines a prognostic high …