User profiles for "author:Heping Zheng"

Heping Zheng

University of Virginia
Verified email at iwonka.med.virginia.edu
Cited by 2261

New paradigms in cell adaptation: decades of discoveries on the CrRLK1L receptor kinase signalling network

S Zhu, Q Fu, F Xu, H Zheng, F Yu - New Phytologist, 2021 - Wiley Online Library
Summary Receptor‐like kinases (RLKs), which constitute the largest receptor family in
plants, are essential for perceiving and relaying information about various environmental …

X-ray crystallography over the past decade for novel drug discovery–where are we heading next?

H Zheng, KB Handing, MD Zimmerman… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: Macromolecular X-ray crystallography has been the primary methodology for
determining the three-dimensional structures of proteins, nucleic acids and viruses …

The future of crystallography in drug discovery

H Zheng, J Hou, MD Zimmerman… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: X-ray crystallography plays an important role in structure-based drug design
(SBDD), and accurate analysis of crystal structures of target macromolecules and …

Data mining of metal ion environments present in protein structures

H Zheng, M Chruszcz, P Lasota, L Lebioda… - Journal of inorganic …, 2008 - Elsevier
Analysis of metal–protein interaction distances, coordination numbers, B-factors
(displacement parameters), and occupancies of metal-binding sites in protein structures …

[HTML][HTML] CheckMyMetal: a macromolecular metal-binding validation tool

H Zheng, DR Cooper, PJ Porebski… - … Section D: Structural …, 2017 - scripts.iucr.org
Metals are essential in many biological processes, and metal ions are modeled in roughly
40% of the macromolecular structures in the Protein Data Bank (PDB). However, a …

Validation of metal-binding sites in macromolecular structures with the CheckMyMetal web server

H Zheng, MD Chordia, DR Cooper, M Chruszcz… - Nature protocols, 2014 - nature.com
Metals have vital roles in both the mechanism and architecture of biological
macromolecules. Yet structures of metal-containing macromolecules in which metals are …

[HTML][HTML] Inner superhydrophobic materials based on waste fly ash: microstructural morphology of microetching effects

B Pang, H Zheng, Z Jin, D Hou, Y Zhang, X Song… - Composites Part B …, 2024 - Elsevier
Superhydrophobic technology in construction can effectively improve the barrier ability of the
substrate to harmful water-based erosion media, among which the coating scheme is the …

[HTML][HTML] Crowdsourcing to expand HIV testing among men who have sex with men in China: a closed cohort stepped wedge cluster randomized controlled trial

W Tang, C Wei, B Cao, D Wu, KT Li, H Lu, W Ma… - PLoS …, 2018 - journals.plos.org
Background HIV testing rates are suboptimal among at-risk men. Crowdsourcing may be a
useful tool for designing innovative, community-based HIV testing strategies to increase HIV …

A public database of macromolecular diffraction experiments

M Grabowski, KM Langner, M Cymborowski… - … Section D: Structural …, 2016 - scripts.iucr.org
The low reproducibility of published experimental results in many scientific disciplines has
recently garnered negative attention in scientific journals and the general media. Public …

Characterizing metal-binding sites in proteins with X-ray crystallography

KB Handing, E Niedzialkowska, IG Shabalin… - Nature protocols, 2018 - nature.com
Metals have crucial roles in many physiological, pathological, toxicological, pharmaceutical,
and diagnostic processes. Proper handling of metal-containing macromolecule samples for …