User profiles for "author:Heping Zheng"
Heping ZhengUniversity of Virginia Verified email at iwonka.med.virginia.edu Cited by 2261 |
New paradigms in cell adaptation: decades of discoveries on the CrRLK1L receptor kinase signalling network
Summary Receptor‐like kinases (RLKs), which constitute the largest receptor family in
plants, are essential for perceiving and relaying information about various environmental …
plants, are essential for perceiving and relaying information about various environmental …
X-ray crystallography over the past decade for novel drug discovery–where are we heading next?
H Zheng, KB Handing, MD Zimmerman… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: Macromolecular X-ray crystallography has been the primary methodology for
determining the three-dimensional structures of proteins, nucleic acids and viruses …
determining the three-dimensional structures of proteins, nucleic acids and viruses …
The future of crystallography in drug discovery
H Zheng, J Hou, MD Zimmerman… - Expert opinion on …, 2014 - Taylor & Francis
Introduction: X-ray crystallography plays an important role in structure-based drug design
(SBDD), and accurate analysis of crystal structures of target macromolecules and …
(SBDD), and accurate analysis of crystal structures of target macromolecules and …
Data mining of metal ion environments present in protein structures
H Zheng, M Chruszcz, P Lasota, L Lebioda… - Journal of inorganic …, 2008 - Elsevier
Analysis of metal–protein interaction distances, coordination numbers, B-factors
(displacement parameters), and occupancies of metal-binding sites in protein structures …
(displacement parameters), and occupancies of metal-binding sites in protein structures …
[HTML][HTML] CheckMyMetal: a macromolecular metal-binding validation tool
Metals are essential in many biological processes, and metal ions are modeled in roughly
40% of the macromolecular structures in the Protein Data Bank (PDB). However, a …
40% of the macromolecular structures in the Protein Data Bank (PDB). However, a …
Validation of metal-binding sites in macromolecular structures with the CheckMyMetal web server
Metals have vital roles in both the mechanism and architecture of biological
macromolecules. Yet structures of metal-containing macromolecules in which metals are …
macromolecules. Yet structures of metal-containing macromolecules in which metals are …
[HTML][HTML] Inner superhydrophobic materials based on waste fly ash: microstructural morphology of microetching effects
Superhydrophobic technology in construction can effectively improve the barrier ability of the
substrate to harmful water-based erosion media, among which the coating scheme is the …
substrate to harmful water-based erosion media, among which the coating scheme is the …
[HTML][HTML] Crowdsourcing to expand HIV testing among men who have sex with men in China: a closed cohort stepped wedge cluster randomized controlled trial
Background HIV testing rates are suboptimal among at-risk men. Crowdsourcing may be a
useful tool for designing innovative, community-based HIV testing strategies to increase HIV …
useful tool for designing innovative, community-based HIV testing strategies to increase HIV …
A public database of macromolecular diffraction experiments
M Grabowski, KM Langner, M Cymborowski… - … Section D: Structural …, 2016 - scripts.iucr.org
The low reproducibility of published experimental results in many scientific disciplines has
recently garnered negative attention in scientific journals and the general media. Public …
recently garnered negative attention in scientific journals and the general media. Public …
Characterizing metal-binding sites in proteins with X-ray crystallography
KB Handing, E Niedzialkowska, IG Shabalin… - Nature protocols, 2018 - nature.com
Metals have crucial roles in many physiological, pathological, toxicological, pharmaceutical,
and diagnostic processes. Proper handling of metal-containing macromolecule samples for …
and diagnostic processes. Proper handling of metal-containing macromolecule samples for …