User profiles for "author:G Pons"

Gerard Pons

Centrum Wiskunde & Informatica
Verified email at cwi.nl
Cited by 1090

Facilitation of drug evaluation in children by population methods and modelling

M Tod, V Jullien, G Pons - Clinical pharmacokinetics, 2008 - Springer
The pharmacokinetics and pharmacodynamics of drugs are different in adult and paediatric
populations, the latter being particularly heterogeneous. These differences in …

Drug disposition in cystic fibrosis

E Rey, JM Tréluyer, G Pons - Clinical pharmacokinetics, 1998 - Springer
There are many pathological changes in patients with cystic fibrosis (CF) which can lead to
alterations in drug disposition. Although, in patients with CF, the extent of drug absorption …

Dihydrolipoamide dehydrogenase: functional similarities and divergent evolution of the pyridine nucleotide-disulfide oxidoreductases

DJ Carothers, G Pons, MS Patel - Archives of biochemistry and biophysics, 1989 - Elsevier
Dihydrolipoamide dehydrogenase (E 3) is the common component of the three α-ketoacid
dehydrogenase complexes oxidizing pyruvate, α-ketoglutarate, and the branched-chain α …

Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial

…, A Tran, E Rey, P d'Athis, J Vincent, O Dulac, G Pons - The Lancet, 2000 - thelancet.com
Background Stiripentol is an inhibitor of cytochrome P450 that showed antiepileptic efficacy
in severe myoclonic epilepsy in infancy (SMEI) in association with clobazam and valproate …

Automated breast ultrasound lesions detection using convolutional neural networks

MH Yap, G Pons, J Marti, S Ganau… - IEEE journal of …, 2017 - ieeexplore.ieee.org
Breast lesion detection using ultrasound imaging is considered an important step of
computer-aided diagnosis systems. Over the past decade, researchers have demonstrated …

Multidetector-row computed tomography in the planning of abdominal perforator flaps

…, JA Clavero, JR Larranaga, X Alomar, G Pons… - Journal of plastic …, 2006 - Elsevier
An accurate preoperative evaluation of the vascular anatomy of the abdominal wall is
extremely valuable in improving the surgical strategy in abdominal perforator flaps. The …

Off label and unlicensed drug use among French office based paediatricians

…, C Rougeron, M Mares, G Bréart, G Pons - Archives of disease in …, 2000 - adc.bmj.com
AIMS To determine the extent of off label and unlicensed drug use in French office based
paediatric practice. METHODS A prospective one day survey of all written prescriptions, for …

Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 …

…, B Mangum, B Murphy, D Murray, G Pons… - The Lancet …, 2015 - thelancet.com
Background Preclinical data suggest that the loop-diuretic bumetanide might be an effective
treatment for neonatal seizures. We aimed to assess dose and feasibility of intravenous …

A randomized, double‐blind, multicentre controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children

L Bertin, G Pons, P d'Athis, JF Duhamel… - Fundamental & …, 1996 - Wiley Online Library
Two hundred and nineteen children (boys: 56%, girls: 44%) were included in a randomized,
double‐blind, multicentre (4 centres) controlled trial designed to assess the efficacy and …

Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells

…, D Colomer, E Montserrat, G Pons… - Blood, The Journal …, 1998 - ashpublications.org
We analyzed the effect of aspirin, salicylate, and other nonsteroidal antiinflammatory drugs
(NSAIDs) on the viability of B-chronic lymphocytic leukemia (B-CLL) cells. Aspirin induced a …