Efavirenz: a review

SME Vrouenraets, FWNM Wit, J Tongeren… - Expert opinion on …, 2007 - Taylor & Francis
Efavirenz is a non-nucleoside reverse transcriptase inhibitor that in most treatment
guidelines is recommended to be taken combined with two nucleoside analogue reverse …

Cross-sectional Comparison of the Prevalence of Age-Associated Comorbidities and Their Risk Factors Between HIV-Infected and Uninfected Individuals: The AGEh …

J Schouten, FW Wit, IG Stolte… - Clinical Infectious …, 2014 - academic.oup.com
Age-associated comorbidities (cardiovascular and renal disease) were more prevalent
among HIV-positive compared with HIV-uninfected patients. Comorbidity was associated …

[HTML][HTML] Hypertension in sub-Saharan Africa: cross-sectional surveys in four rural and urban communities

ME Hendriks, FWNM Wit, MTL Roos, LM Brewster… - PloS one, 2012 - journals.plos.org
Background Cardiovascular disease (CVD) is the leading cause of adult mortality in low-
income countries but data on the prevalence of cardiovascular risk factors such as …

Hepatitis B and C virus co-infection and the risk for hepatotoxicity of highly active antiretroviral therapy in HIV-1 infection

M Den Brinker, FWNM Wit, PME Wertheim-van Dillen… - Aids, 2000 - journals.lww.com
Objective To investigate the risk of hepatotoxicity after initiation of protease inhibitor-
containing highly active antiretroviral therapy (HAART) for HIV-1 infected patients with …

Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus

EH Sohn, HW van Dijk, C Jiao… - Proceedings of the …, 2016 - National Acad Sciences
Diabetic retinopathy (DR) has long been recognized as a microvasculopathy, but retinal
diabetic neuropathy (RDN), characterized by inner retinal neurodegeneration, also occurs in …

Incidence of and risk factors for severe hepatotoxicity associated with antiretroviral combination therapy

FWNM Wit, GJ Weverling, J Weel… - The Journal of …, 2002 - academic.oup.com
This retrospective cohort study investigated whether particular antiretroviral agents are
associated with a higher risk for developing grade 4 liver enzyme elevations (LEEs) in …

HIV-1 drug resistance in antiretroviral-naive individuals in sub-Saharan Africa after rollout of antiretroviral therapy: a multicentre observational study

RL Hamers, CL Wallis, C Kityo, M Siwale… - The Lancet infectious …, 2011 - thelancet.com
Background There are few data on the epidemiology of primary HIV-1 drug resistance after
the roll-out of antiretroviral treatment (ART) in sub-Saharan Africa. We aimed to assess the …

Effect of pretreatment HIV-1 drug resistance on immunological, virological, and drug-resistance outcomes of first-line antiretroviral treatment in sub-Saharan Africa: a …

RL Hamers, R Schuurman, KCE Sigaloff… - The Lancet infectious …, 2012 - thelancet.com
Background The effect of pretreatment HIV-1 drug resistance on the response to first-line
combination antiretroviral therapy (ART) in sub-Saharan Africa has not been assessed. We …

Increased brain-predicted aging in treated HIV disease

JH Cole, J Underwood, MWA Caan, D De Francesco… - Neurology, 2017 - AAN Enterprises
Objective: To establish whether HIV disease is associated with abnormal levels of age-
related brain atrophy, by estimating apparent brain age using neuroimaging and exploring …

Long-term mortality in HIV-positive individuals virally suppressed for> 3 years with incomplete CD4 recovery

FN Engsig, R Zangerle, O Katsarou… - Clinical infectious …, 2014 - academic.oup.com
Background. Some human immunodeficiency virus (HIV)–infected individuals initiating
combination antiretroviral therapy (cART) with low CD4 counts achieve viral suppression but …