This review discusses advances in knowledge regarding the composition and structure of
bone, the modeling and remodeling of bone, the formation of bone during growth and its …

There is no one cause of bone fragility; genetic and environmental factors play a part in
development of smaller bones, fewer or thinner trabeculae, and thin cortices, all of which …

Biochemical measurements of bone turnover are helpful in the study of the pathophysiology
of skeletal metabolism and growth. However, interpretation of their results is difficult because …

Background Osteoporotic structural damage and bone fragility result from reduced bone
formation and increased bone resorption. In a phase 2 clinical trial, strontium ranelate, an …

The incidence of all non-vertebral fractures, as well as the relation to bone mineral density
(BMD), was quantified in 7806 men and women from the Rotterdam Study, a prospective …

Background: Strontium ranelate, a new oral drug shown to reduce vertebral fracture risk in
postmenopausal women with osteoporosis, was studied in the Treatment of Peripheral …

Background Postmenopausal osteoporosis is a serious health problem, and additional
treatments are needed. Methods We studied the effects of oral alendronate, an …

ContextVertebral fractures significantly increase lifetime risk of future fractures, but risk of
further vertebral fractures in the period immediately following a vertebral fracture has not …

Background Osteoporosis research has focused on vertebral fractures and trabecular bone
loss. However, non-vertebral fractures at predominantly cortical sites account for 80% of all …

To determine whether premenopausal daughters of women with postmenopausal
osteoporosis have lower bone mass than other women of the same age, we measured the …