Objective assessment of adherence to inhalers by patients with chronic obstructive pulmonary disease

…, J Seheult, D Seow, F Rawat, E MacHale… - American journal of …, 2017 - atsjournals.org
Rationale: Objective adherence to inhaled therapy by patients with chronic obstructive
pulmonary disease (COPD) has not been reported. Objectives: To objectively quantify …

A randomised clinical trial of feedback on inhaler adherence and technique in patients with severe uncontrolled asthma

I Sulaiman, G Greene, E MacHale… - European …, 2018 - Eur Respiratory Soc
In severe asthma, poor control could reflect issues of medication adherence or inhaler
technique, or that the condition is refractory. This study aimed to determine if an intervention …

[HTML][HTML] A method to assess adherence in inhaler use through analysis of acoustic recordings of inhaler events

S D'Arcy, E MacHale, J Seheult, MS Holmes… - PloS one, 2014 - journals.plos.org
Rationale Poor adherence to inhaler use can be due to poor temporal and/or technique
adherence. Up until now there has been no way of reliably tracking both these factors in …

Irregular and ineffective: a quantitative observational study of the time and technique of inhaler use

I Sulaiman, J Seheult, E MacHale, S D'Arcy… - The Journal of Allergy …, 2016 - Elsevier
Background Cross-sectional observational studies suggest that between 50% and 60% of
patients misuse a dry powder inhaler, whereas studies with electronic monitors indicate that …

Personalized biofeedback on inhaler adherence and technique by community pharmacists: a cluster randomized clinical trial

S O'Dwyer, G Greene, E MacHale, B Cushen… - The Journal of Allergy …, 2020 - Elsevier
Background Guidelines recommend that patients treated with inhalers receive adherence
counseling and device training. Digital technologies that assess both inhaler adherence and …

The acoustic features of inhalation can be used to quantify aerosol delivery from a Diskus™ dry powder inhaler

…, T Bholah, H Al Bannai, I Sulaiman, E MacHale… - Pharmaceutical …, 2014 - Springer
Purpose Some patients are unable to generate the peak inspiratory flow rate (PIFR)
necessary to de-agglomerate drug particles from dry powder inhalers (DPIs). In this study we …

A method to calculate adherence to inhaled therapy that reflects the changes in clinical features of asthma

I Sulaiman, J Seheult, E MacHale, F Boland… - Annals of the …, 2016 - atsjournals.org
Rationale: Currently, studies on adherence to inhaled medications report average
adherence over time. This measure does not account for variations in the interval between …

The clinical impact of different adherence behaviors in patients with severe chronic obstructive pulmonary disease

…, I Sulaiman, G Greene, E MacHale… - American journal of …, 2018 - atsjournals.org
Methods This prospective, observational cohort study recruited hospitalized patients with
known COPD who had already been prescribed a salmeterol/fluticasone propionate Diskus …

[HTML][HTML] Personalising adherence-enhancing interventions using a smart inhaler in patients with COPD: an exploratory cost-effectiveness analysis

…, B Cushen, I Sulaiman, G Greene, E MacHale… - NPJ primary care …, 2018 - nature.com
Four inhaler adherence clusters have been identified using the INCA audio device in COPD
patients:(1) regular use/good technique,(2) regular use/frequent technique errors,(3) …

[HTML][HTML] Long-term cost-effectiveness of digital inhaler adherence technologies in difficult-to-treat asthma

…, JK Sont, TRJ Schermer, E MacHale… - The Journal of Allergy …, 2023 - Elsevier
Background Digital inhalers can monitor inhaler usage, support difficult-to-treat asthma
management, and inform step-up treatment decisions yet their economic value is unknown …