Reconstructing native American population history
D Reich, N Patterson, D Campbell, A Tandon… - Nature, 2012 - nature.com
The peopling of the Americas has been the subject of extensive genetic, archaeological and
linguistic research; however, central questions remain unresolved,,,,. One contentious issue …
linguistic research; however, central questions remain unresolved,,,,. One contentious issue …
Mental health and health behaviours before and during the initial phase of the COVID-19 lockdown: longitudinal analyses of the UK Household Longitudinal Study
Background There are concerns that COVID-19 mitigation measures, including the
'lockdown', may have unintended health consequences. We examined trends in mental …
'lockdown', may have unintended health consequences. We examined trends in mental …
The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder,
starting in early childhood and persisting into adulthood in the majority of cases. Family and …
starting in early childhood and persisting into adulthood in the majority of cases. Family and …
The emerging molecular architecture of schizophrenia, polygenic risk scores and the clinical implications for GxE research
C Iyegbe, D Campbell, A Butler, O Ajnakina… - Social psychiatry and …, 2014 - Springer
Schizophrenia is a devastating mental disorder. The level of risk in the general population is
sustained by the persistence of social, environmental and biological factors, as well as their …
sustained by the persistence of social, environmental and biological factors, as well as their …
[HTML][HTML] Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture
LK Davis, D Yu, CL Keenan, ER Gamazon… - PLoS …, 2013 - journals.plos.org
The direct estimation of heritability from genome-wide common variant data as implemented
in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to …
in the program Genome-wide Complex Trait Analysis (GCTA) has provided a means to …
DSM‐IV combined type ADHD shows familial association with sibling trait scores: A sampling strategy for QTL linkage
Attention deficit hyperactivity disorder (ADHD) is a discrete clinical syndrome characterized
by the triad of inattention, hyperactivity, and impulsivity in the context of marked impairments …
by the triad of inattention, hyperactivity, and impulsivity in the context of marked impairments …
Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette's syndrome and OCD
D Yu, CA Mathews, JM Scharf… - American Journal of …, 2015 - Am Psychiatric Assoc
Objective: Obsessive-compulsive disorder (OCD) and Tourette's syndrome are highly
heritable neurodevelopmental disorders that are thought to share genetic risk factors …
heritable neurodevelopmental disorders that are thought to share genetic risk factors …
CYP2C19 genotype predicts steady state escitalopram concentration in GENDEP
P Huezo-Diaz, N Perroud, EP Spencer… - Journal of …, 2012 - journals.sagepub.com
In vitro work shows CYP2C19 and CYP2D6 contribute to the metabolism of escitalopram to
its primary metabolite, N-desmethylescitalopram. We report the effect of CYP2C19 and …
its primary metabolite, N-desmethylescitalopram. We report the effect of CYP2C19 and …
[HTML][HTML] CNV Analysis in Tourette Syndrome Implicates Large Genomic Rearrangements in COL8A1 and NRXN1
A Nag, EG Bochukova, B Kremeyer, DD Campbell… - Plos one, 2013 - journals.plos.org
Tourette syndrome (TS) is a neuropsychiatric disorder with a strong genetic component.
However, the genetic architecture of TS remains uncertain. Copy number variation (CNV) …
However, the genetic architecture of TS remains uncertain. Copy number variation (CNV) …
[HTML][HTML] Biases arising from linked administrative data for epidemiological research: a conceptual framework from registration to analyses
RJ Shaw, KL Harron, JM Pescarini… - European journal of …, 2022 - Springer
Linked administrative data offer a rich source of information that can be harnessed to
describe patterns of disease, understand their causes and evaluate interventions. However …
describe patterns of disease, understand their causes and evaluate interventions. However …