User profiles for "author:David Melzer"

David Melzer

Professor of Epidemiology and Public Health, University of Exeter
Verified email at exeter.ac.uk
Cited by 40656

Social inequalities and the common mental disorders: a systematic review of the evidence

T Fryers, D Melzer, R Jenkins - Social psychiatry and psychiatric …, 2003 - Springer
Background: Of two large-scale government-commissioned studies of common mental
disorders in the UK, one found occupational social class to be the strongest marker of risk …

The current landscape for direct-to-consumer genetic testing: legal, ethical, and policy issues

S Hogarth, G Javitt, D Melzer - Annu. Rev. Genomics Hum …, 2008 - annualreviews.org
This review surveys the developing market for direct-to-consumer (DTC) genetic tests and
examines the range of companies and tests available, the regulatory landscape, the …

[HTML][HTML] The distribution of the common mental disorders: social inequalities in Europe

T Fryers, D Melzer, R Jenkins, T Brugha - Clinical Practice and …, 2005 - Springer
Background The social class distribution of the common mental disorders (mostly anxiety
and/or depression) has been in doubt until recently. This paper reviews the evidence of …

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

J Dupuis, C Langenberg, I Prokopenko, R Saxena… - Nature …, 2010 - nature.com
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …

A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity

TM Frayling, NJ Timpson, MN Weedon, E Zeggini… - Science, 2007 - science.org
Obesity is a serious international health problem that increases the risk of several common
diseases. The genetic factors predisposing to obesity are poorly understood. A genome …

Systematic identification of trans eQTLs as putative drivers of known disease associations

HJ Westra, MJ Peters, T Esko, H Yaghootkar… - Nature …, 2013 - nature.com
Identifying the downstream effects of disease-associated SNPs is challenging. To help
overcome this problem, we performed expression quantitative trait locus (eQTL) meta …

Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults

IA Lang, TS Galloway, A Scarlett, WE Henley… - Jama, 2008 - jamanetwork.com
Context Bisphenol A (BPA) is widely used in epoxy resins lining food and beverage
containers. Evidence of effects in animals has generated concern over low-level chronic …

Vitamin D and risk of cognitive decline in elderly persons

DJ Llewellyn, IA Lang, KM Langa… - Archives of internal …, 2010 - jamanetwork.com
Background To our knowledge, no prospective study has examined the association between
vitamin D and cognitive decline or dementia. Methods We determined whether low levels of …

[HTML][HTML] DNA methylation-based measures of biological age: meta-analysis predicting time to death

BH Chen, RE Marioni, E Colicino, MJ Peters… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
Estimates of biological age based on DNA methylation patterns, often referred to as
“epigenetic age”,“DNAm age”, have been shown to be robust biomarkers of age in humans …

Preexisting comorbidities predicting COVID-19 and mortality in the UK biobank community cohort

JL Atkins, JAH Masoli, J Delgado… - The Journals of …, 2020 - academic.oup.com
Background Hospitalized COVID-19 patients tend to be older and frequently have
hypertension, diabetes, or coronary heart disease, but whether these comorbidities are true …