Executive summary Pollution is the largest environmental cause of disease and premature
death in the world today. Diseases caused by pollution were responsible for an estimated 9 …

Genome-wide association studies have identified hundreds of genetic variants associated
with complex human diseases and traits, and have provided valuable insights into their …

PURPOSE: To develop concise, patient-focussed, up to date, evidence-based, expert
consensus recommendations for the management of hip and knee osteoarthritis (OA), which …

Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …

OBJECTIVE: To update evidence for available therapies in the treatment of hip and knee
osteoarthritis (OA) and to examine whether research evidence has changed from 31 …

By combining genome-wide association data from 8,130 individuals with type 2 diabetes
(T2D) and 38,987 controls of European descent and following up previously unidentified …

Objective To develop concise, up-to-date, patient-focused, evidence-based, expert
consensus guidelines for the management of knee osteoarthritis (OA), intended to inform …

Summary The Lancet Commission on pollution and health reported that pollution was
responsible for 9 million premature deaths in 2015, making it the world's largest …

Background Insulin-like growth factor (IGF)-I, a mitogenic and antiapoptotic peptide, can
affect the proliferation of breast epithelial cells, and is thought to have a role in breast …

We conducted a genome-wide association study (GWAS) of breast cancer by genotyping
528,173 SNPs in 1,145 postmenopausal women of European ancestry with invasive breast …