We have identified and characterized two genes in Drosophila whose products are required
for activated RAS to signal with normal efficiency, but do not appear to effect signaling by …

The broad-spectrum herbicide glyphosate (common trade name “Roundup”) was first sold to
farmers in 1974. Since the late 1970s, the volume of glyphosate-based herbicides (GBHs) …

Environmental chemicals have significant impacts on biological systems. Chemical
exposures during early stages of development can disrupt normal patterns of development …

An important requirement for physiologic homeostasis is the detoxification and removal of
endogenous hormones and xenobiotic compounds with biological activity. Much of the …

Over the last two decades, the incidence of obesity and associated metabolic syndrome
diseases has risen dramatically, becoming a global health crisis. Increased caloric intake …

This study analyzer, the function of the homeobox gene goosecold in Xenopus
development. First, we find that gooaecoid mFiNA distribution closely mimics the expected …

The recent epidemics of metabolic diseases, obesity, type 2 diabetes (T2D), liver lipid
disorders and metabolic syndrome have largely been attributed to genetic background and …

The western clawed frog Xenopus tropicalis is an important model for vertebrate
development that combines experimental advantages of the African clawed frog Xenopus …

The freshwater cnidarian Hydra was first described in 1702 and has been the object of study
for 300 years. Experimental studies of Hydra between 1736 and 1744 culminated in the …

The cytochrome CYP3A gene products, expressed in mammalian liver, are essential for the
metabolism of lipophilic substrates, including endogenous steroid hormones and …