Purpose Endometrial cancers have long been divided into estrogen-dependent type I and
the less common clinically aggressive estrogen-independent type II. Little is known about …

Population statistics indicate that age-adjusted breast-cancer mortality rates began to
decline during the early 1990s in many developed countries. For several decades before …

Four authoritative reviews of active smoking and breast cancer have been published since
2000, but only one considered data after 2002 and conclusions varied. Three reviews of …

Background The effect of screening with prostate-specific–antigen (PSA) testing and digital
rectal examination on the rate of death from prostate cancer is unknown. This is the first …

Exposure to ambient fine particulate matter (PM2. 5) is a major global health concern.
Quantitative estimates of attributable mortality are based on disease-specific hazard ratio …

Context Screening for ovarian cancer with cancer antigen 125 (CA-125) and transvaginal
ultrasound has an unknown effect on mortality. Objective To evaluate the effect of screening …

Background The prostate component of the Prostate, Lung, Colorectal, and Ovarian (PLCO)
Cancer Screening Trial was undertaken to determine whether there is a reduction in …

Background The benefits of endoscopic testing for colorectal-cancer screening are
uncertain. We evaluated the effect of screening with flexible sigmoidoscopy on colorectal …

Objective.—To assess the risk of invasive breast cancer associated with total and beverage-
specific alcohol consumption and to evaluate whether dietary and nondietary factors modify …

The association between anthropometric indices and the risk of breast cancer was analyzed
using pooled data from seven prospective cohort studies. Together, these cohorts comprise …