User profiles for "author:Alessandro Giuliani"

Alessandro Giuliani

Istituto Superiore di Sanità
Verified email at iss.it
Cited by 17963

Protein contact networks: an emerging paradigm in chemistry

L Di Paola, M De Ruvo, P Paci, D Santoni… - Chemical …, 2013 - ACS Publications
Topology is at the very heart of chemistry. This stems from the fact that chemical thought,
since its prescientific alchemic origins, focused on the mutual relations between different …

Quantitative structure− activity relationships of mutagenic and carcinogenic aromatic amines

R Benigni, A Giuliani, R Franke, A Gruska - Chemical Reviews, 2000 - ACS Publications
Among the various toxicity endpoints, chemical carcinogenicity is of primary interest
because it drives much of the current regulatory actions on new and existing chemicals and …

The application of principal component analysis to drug discovery and biomedical data

A Giuliani - Drug discovery today, 2017 - Elsevier
Highlights•Principal Component Analysis provides a general frame for systemic approaches
in pharmacology.•Principal components correspond to the latent factors of a data …

Detecting deterministic signals in exceptionally noisy environments using cross-recurrence quantification

JP Zbilut, A Giuliani, CL Webber Jr - Physics Letters A, 1998 - Elsevier
The demonstrated ability of recurrence quantification analysis to detect very subtle patterns
in time series was exploited to devise a filter able to recognize and extract signals buried in …

Genome-wide expression profile of sporadic gastric cancers with microsatellite instability

M D'Errico, E de Rinaldis, MF Blasi, V Viti… - European journal of …, 2009 - Elsevier
Gastric cancers with mismatch repair (MMR) inactivation are characterised by microsatellite
instability (MSI). In this study, the transcriptional profile of 38 gastric cancers with and without …

[HTML][HTML] Cell fate decision as high-dimensional critical state transition

M Mojtahedi, A Skupin, J Zhou, IG Castaño… - PLoS …, 2016 - journals.plos.org
Cell fate choice and commitment of multipotent progenitor cells to a differentiated lineage
requires broad changes of their gene expression profile. But how progenitor cells overcome …

Nerve growth factor control of neuronal expression of angiogenetic and vasoactive factors

L Calza, L Giardino, A Giuliani, L Aloe… - Proceedings of the …, 2001 - National Acad Sciences
In postnatal tissues, angiogenesis occurs in nontumoral conditions on appropriate stimuli. In
the nervous tissue, hypoxia, neural graft, increased neural function, and synaptic activity are …

[HTML][HTML] A specific mutational signature associated with DNA 8-oxoguanine persistence in MUTYH-defective colorectal cancer

A Viel, A Bruselles, E Meccia, M Fornasarig, M Quaia… - …, 2017 - thelancet.com
Oxoguanine, a common mutagenic DNA lesion, generates G: C> T: A transversions via
mispairing with adenine during DNA replication. When operating normally, the MUTYH DNA …

Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome

P Bianchi, E Ciani, S Guidi, S Trazzi… - Journal of …, 2010 - Soc Neuroscience
Down syndrome (DS) is a genetic pathology characterized by intellectual disability and brain
hypotrophy. Widespread neurogenesis impairment characterizes the fetal and neonatal DS …

Protein contact network topology: a natural language for allostery

L Di Paola, A Giuliani - Current opinion in structural biology, 2015 - Elsevier
Highlights•The paper surveys the most recent applications of graph theory to protein
allostery.•The reunification of allostery molecular models passes through topology of protein …