User profiles for "author:Alessandro Giuliani"
Alessandro GiulianiIstituto Superiore di Sanità Verified email at iss.it Cited by 17963 |
Protein contact networks: an emerging paradigm in chemistry
Topology is at the very heart of chemistry. This stems from the fact that chemical thought,
since its prescientific alchemic origins, focused on the mutual relations between different …
since its prescientific alchemic origins, focused on the mutual relations between different …
Quantitative structure− activity relationships of mutagenic and carcinogenic aromatic amines
R Benigni, A Giuliani, R Franke, A Gruska - Chemical Reviews, 2000 - ACS Publications
Among the various toxicity endpoints, chemical carcinogenicity is of primary interest
because it drives much of the current regulatory actions on new and existing chemicals and …
because it drives much of the current regulatory actions on new and existing chemicals and …
The application of principal component analysis to drug discovery and biomedical data
A Giuliani - Drug discovery today, 2017 - Elsevier
Highlights•Principal Component Analysis provides a general frame for systemic approaches
in pharmacology.•Principal components correspond to the latent factors of a data …
in pharmacology.•Principal components correspond to the latent factors of a data …
Detecting deterministic signals in exceptionally noisy environments using cross-recurrence quantification
JP Zbilut, A Giuliani, CL Webber Jr - Physics Letters A, 1998 - Elsevier
The demonstrated ability of recurrence quantification analysis to detect very subtle patterns
in time series was exploited to devise a filter able to recognize and extract signals buried in …
in time series was exploited to devise a filter able to recognize and extract signals buried in …
Genome-wide expression profile of sporadic gastric cancers with microsatellite instability
M D'Errico, E de Rinaldis, MF Blasi, V Viti… - European journal of …, 2009 - Elsevier
Gastric cancers with mismatch repair (MMR) inactivation are characterised by microsatellite
instability (MSI). In this study, the transcriptional profile of 38 gastric cancers with and without …
instability (MSI). In this study, the transcriptional profile of 38 gastric cancers with and without …
[HTML][HTML] Cell fate decision as high-dimensional critical state transition
Cell fate choice and commitment of multipotent progenitor cells to a differentiated lineage
requires broad changes of their gene expression profile. But how progenitor cells overcome …
requires broad changes of their gene expression profile. But how progenitor cells overcome …
Nerve growth factor control of neuronal expression of angiogenetic and vasoactive factors
L Calza, L Giardino, A Giuliani, L Aloe… - Proceedings of the …, 2001 - National Acad Sciences
In postnatal tissues, angiogenesis occurs in nontumoral conditions on appropriate stimuli. In
the nervous tissue, hypoxia, neural graft, increased neural function, and synaptic activity are …
the nervous tissue, hypoxia, neural graft, increased neural function, and synaptic activity are …
[HTML][HTML] A specific mutational signature associated with DNA 8-oxoguanine persistence in MUTYH-defective colorectal cancer
A Viel, A Bruselles, E Meccia, M Fornasarig, M Quaia… - …, 2017 - thelancet.com
Oxoguanine, a common mutagenic DNA lesion, generates G: C> T: A transversions via
mispairing with adenine during DNA replication. When operating normally, the MUTYH DNA …
mispairing with adenine during DNA replication. When operating normally, the MUTYH DNA …
Early pharmacotherapy restores neurogenesis and cognitive performance in the Ts65Dn mouse model for Down syndrome
Down syndrome (DS) is a genetic pathology characterized by intellectual disability and brain
hypotrophy. Widespread neurogenesis impairment characterizes the fetal and neonatal DS …
hypotrophy. Widespread neurogenesis impairment characterizes the fetal and neonatal DS …
Protein contact network topology: a natural language for allostery
L Di Paola, A Giuliani - Current opinion in structural biology, 2015 - Elsevier
Highlights•The paper surveys the most recent applications of graph theory to protein
allostery.•The reunification of allostery molecular models passes through topology of protein …
allostery.•The reunification of allostery molecular models passes through topology of protein …