Randomized trials of complex public health interventions generally aim to identify what
works, accrediting specific intervention 'products' as effective. This approach often fails to …

Objective: To assess the evidence that the association between educational attainment and
risk of HIV infection is changing over time in sub-Saharan Africa. Design and methods …

PURPOSE: This systematic review examined the hypothesis that school institutional factors
influence young people's use of drugs. We aimed to (1) identify the effect of school-level …

Lentiviruses such as HIV-1 traverse nuclear pore complexes (NPC) and infect terminally
differentiated non-dividing cells, but how they do this is unclear. The cytoplasmic NPC …

Abstract Human immunodeficiency virus (HIV)-1 is able to replicate in primary human
macrophages without stimulating innate immunity despite reverse transcription of genomic …

Objectives To determine the impact on teenage pregnancy of interventions that address the
social disadvantage associated with early parenthood and to assess the appropriateness of …

The HIV-1 genome enters cells inside a shell comprised of capsid (CA) protein. Variation in
CA sequence alters HIV-1 infectivity and escape from host restriction factors. However, apart …

The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration
site selection, and is the target of multiple host cell and pharmacologic ligands. However …

The integration of realist evaluation principles within randomised controlled trials ('realist
RCTs') enables evaluations of complex interventions to answer questions about what works …

Background This review synthesises evidence regarding associations between young
people's social networks and their eating behaviours/bodyweight, and also explores how …