Two types of gloves were provided to 85 non-Virginia tobacco harvesters who complained of having "green symptoms." Results show that the use of gloves causes a significant reduction in nicotine absorption as reflected by the nicotine and cotinine excretion rates and also the reduction in the prevalence of "green symptoms," since contact with the leaves and leaf-sap and the abrasions of the palms was avoided by their use. It was found that the use of rubber gloves afforded protection among 93% of the subjects, while with cotton gloves the proportion was somewhat less (78.5%). Cotton gloves were more comfortable but nondurable while the rubber ones were durable but not so comfortable.