Early impact of rotavirus vaccination in a large paediatric hospital in the UK

D Hungerford; J M Read; R P D Cooke; R Vivancos; M Iturriza-Gómara; D J Allen; N French; N Cunliffe

doi:10.1016/j.jhin.2015.12.010

Early impact of rotavirus vaccination in a large paediatric hospital in the UK

J Hosp Infect. 2016 Jun;93(2):117-20. doi: 10.1016/j.jhin.2015.12.010. Epub 2015 Dec 31.

Authors

D Hungerford¹, J M Read², R P D Cooke³, R Vivancos⁴, M Iturriza-Gómara⁵, D J Allen⁶, N French⁵, N Cunliffe⁷

Affiliations

¹ Institute of Infection and Global Health, University of Liverpool, Liverpool, UK; Field Epidemiology Services, Public Health England, Liverpool, UK. Electronic address: d.hungerford@liverpool.ac.uk.
² CHICAS Group, Lancaster Medical School, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.
³ Department of Microbiology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.
⁴ Field Epidemiology Services, Public Health England, Liverpool, UK.
⁵ Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.
⁶ Virus Reference Department, Public Health England, Colindale, London, UK.
⁷ Institute of Infection and Global Health, University of Liverpool, Liverpool, UK; Department of Microbiology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK.

PMID: 26876744
DOI: 10.1016/j.jhin.2015.12.010

Abstract

The impact of routine rotavirus vaccination on community-acquired (CA) and healthcare-associated (HA) rotavirus gastroenteritis (RVGE) at a large paediatric hospital, UK, was investigated over a 13-year period. A total of 1644 hospitalized children aged 0-15 years tested positive for rotavirus between July 2002 and June 2015. Interrupted time-series analysis demonstrated that, post vaccine introduction (July 2013 to June 2015), CA- and HA-RVGE hospitalizations were 83% [95% confidence interval (CI): 72-90%) and 83% (95% CI: 66-92%] lower than expected, respectively. Rotavirus vaccination has rapidly reduced the hospital rotavirus disease burden among both CA- and HA-RVGE cases.

Keywords: Epidemiology; Healthcare-associated infection; Rotavirus; Vaccination.

MeSH terms

Adolescent
Child
Child, Preschool
Community-Acquired Infections / epidemiology
Community-Acquired Infections / prevention & control
Cross Infection / epidemiology
Cross Infection / prevention & control
Female
Gastroenteritis / epidemiology
Gastroenteritis / prevention & control
Hospitals
Humans
Infant
Infant, Newborn
Male
Prevalence
Rotavirus Infections / epidemiology*
Rotavirus Infections / immunology
Rotavirus Infections / prevention & control*
Rotavirus Vaccines / administration & dosage*
Rotavirus Vaccines / immunology
United Kingdom / epidemiology
Vaccination / statistics & numerical data

Substances

Rotavirus Vaccines