Health disparities related to ethnicity are attributed to the complex interaction of social and physical environments, which influence minority health. The prevalence of health problems such as cardiovascular disease, strokes, diabetes, and maternal and child health outcomes exist among African Americans contributing to health disparities. Extensive support systems within the African American community, however, serve to resist disparities in healthcare and improve the health and well-being of community members. This article is an analytical review of current research addressing key factors of the home, the church, the community, and the healthcare system for creating partnerships to enhance community- based research in the African American community. The results of this literature review provide culturally appropriate approaches to eliminating health disparities by building upon the strengths and resources within the African American community. Best practices involve recognizing the pastor as the entry into the community, utilizing a Community-Based Participatory Research process, and establishing trust through open communication and relationship building.