Abstract
Prenatal diethylstilbestrol (DES)-exposed mice have raised the suspicion of a transgenerational effect in the occurrence of genital malformation in males. This nationwide cohort study in collaboration with a French association of DES-exposed women studied 529 families and showed that a significant proportion of boys born to DES daughters exhibited hypospadias with no other molecular defects identified.
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Cohort Effect
-
Cohort Studies
-
Diethylstilbestrol / adverse effects*
-
Endocrine Disruptors / adverse effects*
-
Estrogens, Non-Steroidal / adverse effects*
-
Female
-
France
-
Humans
-
Hypospadias / chemically induced
-
Hypospadias / epidemiology*
-
Hypospadias / genetics
-
Male
-
Maternal Exposure*
-
Pedigree
-
Pregnancy
-
Prenatal Exposure Delayed Effects*
-
Prevalence
-
Risk Assessment
-
Risk Factors
-
Sex Factors
Substances
-
Endocrine Disruptors
-
Estrogens, Non-Steroidal
-
Diethylstilbestrol