Endocrine system can be affected by various organic compounds. The review describes the effects of major industrial solvents on adrenal, thyroid and parathyroid glands in man and experimental animals. Further, their toxicity in pancreas, pituitary, testis and ovary has also been discussed. An attempt has been made to offer a historical and general information on solvent toxicity in endocrine glands. Possible mechanisms, in brief, have also been discussed. Endocrine toxicity caused by industrial solvents deserves more attention than hitherto paid. An understanding of hormonal disorders caused by industrial solvents will be important from occupational health point of view.