Pseudo-observations in survival analysis

Stat Methods Med Res. 2010 Feb;19(1):71-99. doi: 10.1177/0962280209105020. Epub 2009 Aug 4.

Abstract

We review recent work on the application of pseudo-observations in survival and event history analysis. This includes regression models for parameters like the survival function in a single point, the restricted mean survival time and transition or state occupation probabilities in multi-state models, e.g. the competing risks cumulative incidence function. Graphical and numerical methods for assessing goodness-of-fit for hazard regression models and for the Fine-Gray model in competing risks studies based on pseudo-observations are also reviewed. Sensitivity to covariate-dependent censoring is studied. The methods are illustrated using a data set from bone marrow transplantation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult
  • Bone Marrow Transplantation / statistics & numerical data
  • Female
  • Humans
  • Leukemia, Myeloid, Acute / mortality
  • Leukemia, Myeloid, Acute / surgery
  • Male
  • Middle Aged
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / mortality
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / surgery
  • Proportional Hazards Models
  • Regression Analysis*
  • Risk Assessment / statistics & numerical data
  • Survival Analysis*
  • Survival Rate
  • Young Adult