Hostname: page-component-6b989bf9dc-wj8jn Total loading time: 0 Render date: 2024-04-14T06:25:49.406Z Has data issue: false hasContentIssue false

Gestation length and birth weight in relation to intake of marine n-3 fatty acids

Published online by Cambridge University Press:  09 March 2007

Sjúrđur F.Olsen*
Affiliation:
Institute of Epidemiology and Social Medicine, University of Århus, Hoegh-Guldbergsgade 8, DK-Århus C, Denmark
Harald S. Hansen
Affiliation:
Department of Biological Sciences, Royal Danish School of Pharmacy, Copenhagen, Denmark
Niels J. Secher
Affiliation:
Department of Obstetrics and Gynecology, University Hospital of Århus, Århus, Denmark
Benny Jensen
Affiliation:
Technological Laboratory, Ministry of Fisheries, Technical University, Lyngby, Denmark
Brittmarie Sandström
Affiliation:
Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Copenhagen, Denmark
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

It has been hypothesized that marine n-3 fatty acids ingested during pregnancy prolong duration of pregnancy and increase fetal growth rate in humans. By a combined self-administered questionnaire and interview applied in the 30th week of gestation we assessed dietary intake of marine n-3 fatty acids and energy in a population-based sample of 965 pregnant Danish women; in a random 14% subsample we also measured marine n-3 fatty acids relative to arachidonic acid (FA-ratio) in erythrocytes. Mean intake of marine n-3 fatty acids was 0·25 (95% range 0–0·75) g/d. We could detect no association between n-3 fatty acid intake and FA-ratio on the one hand, and gestation length, birth weight and birth length on the other. The analyses were adjusted for maternal height, prepregnant weight, parity and smoking. The conclusion from the study was that within the intake range of this population, marine n-3 fatty acids ingested in the weeks prior to the 30th week of pregnancy seem not to be a predictor of gestation length or fetal growth rate.

Type
Effects of fatty acid composition of the diet
Copyright
Copyright © The Nutrition Society 1995

References

Andersen, H. J., Andersen, L. F. & Fuchs, A. R. (1989). Diet, pre-eclampsia and intrauterine growth retardation Lancet i,1146CrossRefGoogle Scholar
Andrews, F. K., Morgan, J., Sonquist, J. & Klein, L. (1973). Multiple Classification Analysis, 2nd ed. Ann Arbor:University of Michigan.Google Scholar
Dodge, J. T. & Phillips, G. B. (1967). Composition of phospholipids and of phospholipid fatty acids and aldehydes in human red cells. Journal of Lipid Research 8, 667675.CrossRefGoogle ScholarPubMed
Dyerberg, J. & Bang, H. O. (1985). Pre-eclampsia and prostaglandins. Lancet i, 1267.CrossRefGoogle Scholar
England, M. J., Atkinson, P.M. & Sonnendecker, E. W. W. (1987). Pregnancy induced hypertension: will treatment with, dietary eicosapentaenoic, acid be effective Medical Hypotheses 24, 179186.CrossRefGoogle ScholarPubMed
Olsen, S. F., Hansen, H. S., Sandström, B. & Jensen, B. (1995). Erythrocyte levels compared with reported dietary intake of marine n-3 fatty acids in pregnant women. British Journal of Nutrition 73, 387395.CrossRefGoogle ScholarPubMed
Olsen, S. F., Hansen, H. S., Sommer, S., Jensen, B., Sørensen, T. I. A., Secher, N. J. & Zachariassen, P. (1991). Gestational age in relation to marine n-3 fatty acids in maternal erythrocytes: a study of women in the Faroe Islands and Denmark. American Journal of Obstetrics and Gynecology 164, 12031209.CrossRefGoogle ScholarPubMed
Olsen, S. F., Hansen, H. S., Sørensen, T. I. A., Jensen, B., Secher, N. J., Sommer, S. & Knudsen, L. B. (1986).Google Scholar
Intake or marine fat, rich in (n-3)-PUFA, may increase birthweight by prolonging gestation. Lancet ii, 367369.Google Scholar
Olsen, S. F., Olsen, J. & Frische, G. (1990). Does fish consumption during pregnancy increase fetal growth? A study of the size of the newborn, placental weight and gestational age in relation to fish consumption during pregnancy. International Journal of Epidemiology 19, 971977.CrossRefGoogle ScholarPubMed
Olsen, S. F., Sørensen, J. D., Secher, N. J., Hedegaard, M., Henriksen, T. B., Hansen, H. S. & Grant, A. (1992). Randomised controlled, trial of, effect of, fish-oil supplementation on pregnancy duration. Lancet 339, 10031007.CrossRefGoogle ScholarPubMed
Popp-Snijders, C, Schouten, J. A., van Blitterswijk, W. J. & van der Veen, E. A. (1986). Changes in membrane lipid composition of human erythrocytes after dietary supplementation of (n-3) polyunsaturated fatty acids. Maintenance of membrane fluidity. Biochimica et Biophysica Acta 854, 3137.CrossRefGoogle ScholarPubMed
Secher, N. J. & Olsen, S. F. (1990). Fish oil and pre-eclampsia. British Journal of Obstetrics and Gynaecology 67, 10771079.CrossRefGoogle Scholar
Simopoulos, A. P., Kifer, R. R., Martin, R. E. & Barlow, S. M. (editors) (1991). Health Effects of Omega 3 Polyunsaturated Fatty Acids in Seafoods. World Review of Nutrition and Dietetics 66.Google Scholar
SPSS, Inc (1988). SPSS/PC+ V2·0 Base Manual for the IBM PC/XT/AT and PS/2. Chicago: SPSS Inc.Google Scholar
von Shacky, C., Fisher, S. & Weber, P. C. (1985). Long-term effects of dietary marine omega-3 fatty acids upon plasma and cellular lipids, platelet function, and eicosanoid formation in humans. Journal of Clinical Investigation 76, 16261631.CrossRefGoogle Scholar