The "Gardner hypothesis" suggests that an excess of childhood leukaemia near a nuclear reprocessing plant is caused by paternal exposure to ionizing radiation. But the evidence shows that this explanation is wrong.
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References
Craft, A. W. et al. Epidemiol. Comm. Hlth 47, 109–115 (1993).
Heasman, M. A. Kemp, I. W. Urquhart, J. D. & Black, R. Lancet 1, 266 (1986).
Gardner, M. J. Hall, A. J. Downes, S. & Terrell, J. D. Brit. med. J. 295, 822–827 (1987).
Gardner, M. J., Hall, A. J., Downes, S. & Terrell, J. D. Brit. med. J. 295, 819–822 (1987).
Gardner, M. J. et al. Brit. med. J. 300, 423–429 (1990).
Ford, A. M. et al. Nature 363, 358–360 (1993).
Hawkins, M. M. Draper, G. J. & Smith, R. A. Int. J. Cancer 43, 975–978 (1989).
HSE Investigation of Leukaemia and other Cancers in the Children of Male Workers at Sellafield (Health and Safety Executive, Sheffield, 1993).
Kneale, G. W. & Stewart, A. M. Brit. J. Cancer 41, 222–226 (1980).
Neel, J. V. et al. Am. J. hum. Genet. 46, 1053 (1990).
Graham, S. et al. Natn. Cancer Inst. Monogr. 19, 347–371 (1966).
Roman, E. et al. Brit. med. J. 306, 615–621 (1993).
Yoshimoto, Y. et al. Am. J. hum. Genet. 46, 1041 (1990).
Kinlen, L. J., Clarke, K. & Balkwill, A. Brit. med. J., 306, 1153–1158 (1993).
McLaughlin, J. R. et al. Brit. med. J. 307, 959 (1993).
Draper, G. J. Stiller, R. A., Cartwright, R. A., Craft, A. W. Vincent, T. J. Brit. med. J. 306, 89–94 (1993).
Parker, L. et al. Brit. med. J. 307, 966–971 (1993).
Kinlen, L. J. Brit. med. J. 306, 1718–1721 (1993).
French, The Hon Mr Justice The High Court of Justice (Queen's Bench Division) 1990 R No B60 1989 H No. 3689 p. 74 (1993).
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Doll, R., Evans, H. & Darby, S. Paternal exposure not to blame. Nature 367, 678–680 (1994). https://doi.org/10.1038/367678a0
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DOI: https://doi.org/10.1038/367678a0
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