Original articleIncreasing Prevalence of Gastroschisis: Population-based Study in California
Section snippets
Methods
Data were derived from the California Birth Defects Monitoring Program (CBDMP), a population-based active surveillance system for collecting information on births with congenital malformations in California. The data collection procedure consisted of 3 steps: case finding (review of all logs from hospitals and genetic medical centers to find potential cases), culling (chart review to identify the reportable cases from potential cases on the basis of the registry's criteria), and abstracting
Results
Between the years of 1987 and 2003, 908 cases of gastroschisis were diagnosed in 3,526,506 live births and stillbirths in California, resulting in a birth prevalence of 2.57 per 10,000 births; of the 908 cases, there were 863 live births, 40 stillbirths, and 5 therapeutic abortions. The distribution of the California cohort and the birth prevalence of gastroschisis are illustrated in Table I.
In unadjusted analyses (Table II), young, nulliparous mothers who were US-born Hispanics and had less
Discussion
This study demonstrated that the birth prevalence of gastroschisis has been gradually rising in the past 2 decades in California, independent of the 3 most significant risk factors, young maternal age, maternal ethnicity, and young paternal age. The strength of this study was the ascertainment system of the CBDMP. The registry was large, population-based, and also applied consistent detection procedures in the 17-year study period. Limitations of this study included potential incomplete
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2018, Journal of Pediatric SurgeryCitation Excerpt :The prevalence of gastroschisis in California from 1995 to 2012 was 2.7 cases per 10,000 live births, but has increased during this time period from 1.5 to 5.3 cases per 10,000 live births. The increasing prevalence in California is concordant with ongoing concerns of a worldwide increase in the prevalence of gastroschisis [1–7]. The highest risk in California continues to be among mothers who are white, young, and live in rural areas.