Asthma and lower airway diseaseIncreased risk of pertussis in patients with asthma
Section snippets
Methods
The study was approved by the Institutional Review Boards at both Mayo Clinic and Olmsted County Medical Center. This is a retrospective, population-based case-control study of 164 eligible children and adults who had pertussis and 328 age- and sex-matched control subjects during the outbreak of B pertussis infection in Olmsted County, Minnesota, between January 1, 2004, and December 31, 2005. The study compared a history of asthma between pertussis cases and matched control subjects.
Study subjects
The characteristics of the subjects are summarized in Table II.32 Of the 223 reported pertussis cases, 164 were eligible, and 59 were excluded (47 were due to non–Olmsted County residency, and 12 were due to no research authorization). From the pool of eligible control subjects, 328 were matched (2:1) to cases within a median of 34 days from the index date of pertussis (ie, PCR test date for cases). Of the 164 cases, 50.0% were male, and 82% were white. The median age at the index date of
Discussion
Our study results show that asthma is associated with an increased risk of pertussis. The results were still significant after adjusting for the potential covariates and confounders. Our study findings are unlikely to be due to detection bias, which occurs when exposure (asthma status) affects detection of outcome (pertussis). For example, if detection bias significantly affects our study, we might expect to observe a stronger association between a physician’s diagnosis of asthma and the risk
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2024, Allergology InternationalDiphteria-tetanus-pertussis vaccine reduces specific IgE, inflammation and remodelling in an animal model of mite-induced respiratory allergy
2020, VaccineCitation Excerpt :The potential to promote immune responses with a TH1 profile, proving effective as an adjuvant of anti-infection vaccines, has led to interest in analysing the role of MPL of B. pertussis in other types of vaccines, such as those against cancer and allergic diseases. However, the relationship between B. pertussis, which causes pertussis (also known as whooping cough), and respiratory allergy has not yet been fully elucidated [15]. Retrospective population studies assessing the effect of B. pertussis infection on the sensitization and development of respiratory allergic diseases have had conflicting results [15–18].
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2019, Immunology and Allergy Clinics of North AmericaCitation Excerpt :B pertussis has not been associated with the development of asthma, but may infect asthma patients more frequently. After a pertussis outbreak in California and Minnesota, Capili and colleagues69 conducted a population-based, case-control study to determine the prevalence of pertussis and its association with asthma. They reported an increased risk of B pertussis infection among subjects with asthma (adjusted OR for B pertussis infection with preexisting asthma, 1.73; 95% CI, 1.12–2.67; P = .013).
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Supported by the Clinician Scholarly Award from the Mayo Foundation made possible by the Rochester Epidemiology Project (R01-AR30582) from the National Institute of Arthritis and Musculoskeletal and Skin Diseases.
Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest.