Elsevier

Fertility and Sterility

Volume 95, Issue 8, 30 June 2011, Pages 2574-2577
Fertility and Sterility

Correspondence
Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort study

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Prenatal diethylstilbestrol (DES)-exposed mice have raised the suspicion of a transgenerational effect in the occurrence of genital malformation in males. This nationwide cohort study in collaboration with a French association of DES-exposed women studied 529 families and showed that a significant proportion of boys born to DES daughters exhibited hypospadias with no other molecular defects identified.

Key Words

Hypospadias
DES
diethylstilbestrol
estrogens
prevalence
environment
epigenetic

Cited by (0)

N.K. has nothing to disclose. F.P. has nothing to disclose. M.-O.S.-G. has nothing to disclose. J.-P.D. has nothing to disclose. C.S. has nothing to disclose.

The first two authors contributed equally to this article.

This study was supported by University grant no. PHRC UF8270.