Clinical InvestigationCoronary Artery DiseaseTen-year risk of cardiovascular incidence related to diabetes, prediabetes, and the metabolic syndrome
Section snippets
Subjects
The CMCS was a nationwide, multicenter, prospective cohort study on CVD. As previously reported,9, 10 a total of 30 378 subjects 35 to 64 years of age and free of CVD were included with the informed consent. Ninety percent of the participants (n = 27 249) were recruited from the baseline survey in 1992, carried out in 16 centers from 11 provinces of China. In addition, 3129 subjects from Beijing were added in 1996 to 1999. The response rate was 82.1% and 75.0% for the 2 surveys, respectively.
Results
This study revealed the interrelations of MetS and dysglycemia in the middle-aged Chinese population. Among the subjects, 18.2% were defined as having MetS, 21.1% had IFG, and 6.8% had diabetes (Figure 1). The prevalence of MetS in IFG and diabetes was 38.1% and 48.7%, 4.0 and 5.1 times of that in subjects with normal fasting glucose (NFG), respectively. Sixty-two percent of the subjects with MetS had IFG or diabetes, which was 3.1 times of that prevalent in non-MetS. After adjustment for age
Discussion
The MetS consists of a clustering of metabolic risk factors and is associated with increased risk for CVD. One of the features of MetS is impaired glucose regulation. Several reports further indicate that dysglycemia, regardless of its severity, is accompanied by increased risk for CVD.16, 17, 18 To date, the relative contributions of MetS and dysglycemia on CVD risk have not been dissected. For example, Alexander et al6 indicated that most of the risk for CHD associated with diabetes in the US
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This research was supported by the China National Grant on Science and Technology (85-915-01-02), China fundings from Beijing Municipal Bureau of Science and Technology (953850700) (Beijing, China), and Beijing NOVA Program (2003B26) (Beijing, China).