C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in cord serum of twins: Genetic versus environmental regulation☆,☆☆,★,★★
Section snippets
Cord blood samples and placental examination
One hundred ten cord blood samples of twin pairs with gestational ages between 22 and 39 completed weeks were collected, centrifuged as rapidly as possible, and stored at -20° C. The gestational age, gender, birth weight, length, and head circumference of the neonates were recorded. Sixty-one twin pregnancies had occurred spontaneously, 46 were the result of an ovulation induction procedure (including in vitro fertilization), and for 3 pregnancies this information was missing. Fifty-eight of
RESULTS
Table I shows the correlation coefficients of birth weight and the cord serum concentrations of the growth-regulating factors between 105 twin members and 178 pairs of nonsibling singletons with the same gestational age and with birth weights appropriate for gestational age (10th to 90th percentile). After correction for gestational age and gender, IGF-I concentrations but not birth weight or C-peptide and IGF-II concentrations were correlated in singletons; the r of IGF-I concentrations
COMMENT
The data of this study produce evidence that serum insulin concentrations in the fetus are largely determined by the maternal environment, whereas serum IGF-I concentrations in the fetus are almost exclusively genetically determined (Fig. 2). IGF-II and IGFBP-1 concentrations appear to be determined by both their genetic constitution and the maternal environment.
The birth weights and lengths of the twins were primarily determined by their common environment in this study, which probably
Acknowledgements
We thank F.A. Van Assche, MD, and the physicians and midwives of the labor ward for taking the cord blood samples and I. Vandewal for help with the analyses.
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2019, Metabolism: Clinical and ExperimentalCitation Excerpt :It is difficult to draw any firm conclusions based on such a small number of patients (n = 37), but it highlights the importance of including detailed maternal information in future studies to more comprehensively understand their influence on fetal growth regulation. Twin studies have suggested that genetics play an important role with much stronger correlations between cord blood IGF-I levels in monozygotic twins than dizygotic twins [47]. We were unable to address this question in our study, but in the small subset of patients for whom we had maternal height, we did find that maternal height and cord blood IGF-I levels were not associated with one another.
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Polymorphisms in the IGF1 and IGF1R genes and children born small for gestational age: results of large population studies
2008, Best Practice and Research: Clinical Endocrinology and MetabolismCitation Excerpt :Several twin studies have shown that serum IGF1 levels are highly heritable, especially at a young age. Heritability of serum IGF1 levels ranges from 77% to 93% for girls and boys in cord blood and from 54% to 66% in free serum IGF1 levels of 6–18-year-old school girls.10,11 Twin studies of middle-aged subjects and the elderly showed a heritability ranging between 38% and 63%.12,13
Insulin-like growth factor-I in cord blood is predictive of catch-up growth in monozygotic twins with discordant growth
2010, Journal of Clinical Endocrinology and MetabolismCitation Excerpt :Although the SGA twins showed catch-up growth in length/height, with a convergence in height toward the twin partner, most of our SGA twins remained slim in comparison to the genetically identical “control” twin, with an unchanged BMI difference between the twins. There is increasing evidence that the development of metabolic diseases in adulthood is also related to the adverse intrauterine environment (26) and to a catch-up in weight of SGA infants (27–29). In this regard, future follow-up of our patient group will be important.
Implications for prostate cancer of insulin-like growth factor-I (IGF-I) genetic variation and circulating IGF-I levels
2007, Journal of Clinical Endocrinology and Metabolism
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From the Department of Obstetrics and Gynecology,athe Laboratorium voor Experimentele Geneeskunde en Endocrinologie,band the Center for Human Genetics,cKatholieke Universiteit Leuven.
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Supported by a grant for Fundamental Clinical Research No. G. 3C06.93 and research grant No. 3.0157.95 from the Belgian Nationaal Fonds voor Wetenschappelijk Onderzoek (J.V.).
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Reprint requests: J. Verhaeghe, MD, Department of Obstetrics and Gynecology, U.Z. Gasthuisberg, 49 Herestraat, 3000 Leuven, Belgium.
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