A progesterone-dependent immunomodulatory protein alters the Th1Th2 balance

doi:10.1016/0165-0378(96)00964-3

Journal of Reproductive Immunology

Volume 31, Issues 1–2, August 1996, Pages 81-95

https://doi.org/10.1016/0165-0378(96)00964-3 Get rights and content

Abstract

In the presence of progesterone, lymphocytes from pregnant females produce an immunomodulatory protein known as progesterone induced blocking factor (PIBF). We tested the effect of this protein on cytokine production by mitogen-activated lymphocytes. Spleen cells from Balb c mice were incubated with Con A in the presence of absence of PIBF Supernatants from the activated cells were collected and the concentrations of IL-3, IL-4, IL-10 and IFNy were determined by FLISA, In supernatants from spleen cells activated in the presence of PIBF the concentration of IFNy was not substantially different from controls however, the same spleen cells produced significantly more IL-10, IL-3 and IL-4 than those cultured without the progesterone-induced protein. When CD4 and CD8 enriched cell suspensions were used as producers of the cytokines it was found that both populations reacted with an equally increased production of IL-3, IL-4 and IL-10 in the presence of PIBF, Although cytokine-producing Th cells can be identified within the CD4 population. the present findings that involvement of CD8 cells in altered cytokine production cannot be excluded. These data indicate that the PIBF affects the Th1 Th2 balance, and via ahered cytokine ratios it contributes to decreased cell-mediated responses during pregnancy.

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Animal ScienceA progesterone-dependent immunomodulatory protein alters the Th1Th2 balance

Abstract

J. Reprod. Immunol.

Curr. Opin. Immunol.

Int. J. Immunopharmacol.

Res. Immunol.

J. Reprod. Immunol.

J. Reprod. Immunol.

Cell. Immunol.

J. Steroid Biochem. Mol. Biol.

Immunol.Today

Development of rat anti-mouse interleukin 3 monoclonal antibodies which neutralize bioactivity in vitro

J. Immunol.

Differential expression of the immunoregulatory pregnancy associated factor TJ6 EOS [abstract]

Riv. Immunol. Immunofarmacol.

Transfer of antigens and antibodies between mother and fetus

Decidual lymphocytes in normal and pathological human pregnancy

Lymphokines and non-specific cellular lytic effectors at the fetomaternal site affect fetal size and survival

Two types of mouse helper T cell clone. III Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays and monoclonal antibodies

J. Exp. Med.

Modulation of natural killer activity influences resorption rates in CBAxDBA/2 matings

J. Reprod. Immunol.

Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes; an autoregulatory role of IL-10 produced by monocytes

J. Exp. Med.

Two types of mouse helper T cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones

J Exp. Med.

Anti proliferative effect of IFNγ on immune regulation. I. IFNγ inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones

J. Immunol.

Infiltrating decidual natural killer cells are associated with spontaneous abortions in mice

Cell. Immunol.

Familial malignant melanoma of the female genitalia

Obstet. Gynecol. Surv.

Skin graft survival in the uterine lumen of ewes treated with progesterone

Am. J. Reprod. Immunol. Microbiol.

Implication of cytokines in male or female sterility

Regulation of T cell differentiation: in vitro induction of 20α-hydroxysteroid dehydrogenase in splenic lymphocytes from athymic mice by a unique lymphokine

J. Immunol.

The intersex difference in the production of alloantibodies and growth of tumour allografts in mice

Folia. Biol. Praha.

IL-4 and IL-10 deficient mice [abstract]

Animal Science
A progesterone-dependent immunomodulatory protein alters the $Th1 Th2$ balance