Research article
Airway blood flow responses to temperature and humidity of inhaled air

https://doi.org/10.1016/0034-5687(96)00053-9Get rights and content

Abstract

We determined the effect of breathing cold dry air (−39°C, 0.1% relative humidity, RH) and warm humid air (43°C, 100% RH) on airway mucosal blood flow (Q̇aw) in normal human subjects (n = 8, age 25–53 years) at rest. Q̇aw was measured with a dimethylether uptake technique which reflects blood flow in the mucosa of large airways corresponding to a 50 ml anatomical dead-space segment extending distally from the trachea. Mean Q̇aw was 10.1 ± 1.9 ml min−1 (mean ± S.D.) during room air breathing (25°C, 70% RH) and decreased to 4.7 ± 2.1 ml min−1 during cold dry air breathing (p < 0.05). Within 20 min of resuming room air breathing, mean Q̇aw had returned to baseline. Breathing warm humid air had no significant effect on mean Q̇aw (8.2 ± 1.4 ml min−1). These results indicate that quiet breathing of frigid air causes vasoconstriction in central airways.

References (15)

  • E.M. Baile et al.

    Effect of cold and warm dry air hyperventilation on canine airway blood flow

    J. Appl. Physiol.

    (1987)
  • E.M. Baile et al.

    Tracheobronchial and upper airway blood flow in dogs during thermally induced panting

    J. Appl. Physiol.

    (1987)
  • A. Breitenbücher et al.

    Effect of lung volume and intrathoracic pressure on airway mucosal blood flow in man

    Respir. Physiol.

    (1994)
  • W.A. Briscoe et al.

    The relationship between airway resistance, airway conductance and lung volume in subjects of different age and body size

    J. Clin. Invest.

    (1958)
  • M.E. Deffebach et al.

    The bronchial circulation: Small, but a vital attribute of the lung

    Am. Rev. Respir. Dis.

    (1987)
  • S. Elsasser et al.

    Independent control of mucosal and total airway blood flow during hypoxemia

    J. Appl. Physiol.

    (1991)
  • J.E. Fish et al.

    Airway responses to methacholine in allergic and nonallergic subjects

    Am. Rev. Respir. Dis.

    (1976)
There are more references available in the full text version of this article.

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