A comparison of positive family history definitions for defining risk of future disease☆
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Dairy product consumption and calcified atherosclerotic plaques in the coronary arteries: The NHLBI Family Heart Study
2022, Clinical Nutrition ESPENCitation Excerpt :The details of the NHLBI FHS have been described in detail elsewhere [18]. In short, families contributing to the study were randomly selected (random group) or selected due to a higher-than-expected risk of CHD (high-risk group) from existing population-based cohort studies [19] (Supplemental Fig. 1). The largest families that underwent additional typing of genome-wide anonymous markers by the Mammalian Genotyping Service were invited between 2002 and 2003 for further examination that included cardiac-gated multi-detector computed tomography (cardiac CT) with coronary artery calcium (CAC) scoring.
The Role of Family Health History in Predicting Midlife Chronic Disease Outcomes
2021, American Journal of Preventive MedicineCitation Excerpt :Determining the level of generational complexity needed may further complicate risk prediction. In the example of CVD and some cancers, evidence exists for the importance of knowledge about first-degree relatives.29–38 However, there is increasing recognition of the relevance of histories from multiple generations in assessing the risk for malignancies, CVD, hypertension, and depression,16,39–43 particularly for early onset of these conditions.39,41–44
Inferring Transmission Histories of Rare Alleles in Population-Scale Genealogies
2018, American Journal of Human GeneticsFamily History in the Primary Open-Angle African American Glaucoma Genetics Study Cohort
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This study was supported by Grants HL24855 and HL21088 from the National Heart Lung and Blood Institute and a grant from the Thrasher Research Fund.