Serum amyloid A (SAA): an acute phase protein and apolipoprotein

doi:10.1016/0021-9150(93)90155-N

Atherosclerosis

Volume 102, Issue 2, September 1993, Pages 131-146

https://doi.org/10.1016/0021-9150(93)90155-N Get rights and content

Abstract

Serum amyloid A (SAA) proteins comprise a family of apolipoproteins coded for by at least three genes with allelic variation and a high degree of homology between species. The synthesis of certain members of the family is greatly increased in inflammation. However, SAA is not often used as an acute-phase marker despite being at least as sensitive as C-reactive protein. SAA proteins can be considered as apolipoproteins since they associate with plasma lipoproteins mainly within the high density range, perhaps through amphipathic a-helical structure. It is not known why certain subjects expressing SAA develop secondary systemic amyloidosis. There is still no specific function attributed to SAA; however, a popular hypothesis suggests that SAA may modulate metabolism of high density lipoproteins (HDL). This may impede the protective function of HDL against the development of atherosclerosis. The potential significance of the association between SAA and lipoproteins needs further evaluation.

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Review articleSerum amyloid A (SAA): an acute phase protein and apolipoprotein

Abstract

Med. Hypotheses

Blood

J. Biol. Chem.

Biochem. Biophys. Res. Commun.

FEBS Lett.

Comp. Biochem. Physiol. (B)

J. Biol. Chem.

Gene

Biochem. Biophys. Res. Commun.

J. Biol. Chem.

J. Biol. Chem.

J. Biol. Chem.

Biochem. Biophys. Res. Commun.

Biochem. Biophys. Res. Commun.

Biochem. Biophys. Res. Commun.

Biochim. Biophys. Acta

Biochem. Biophys. Res. Commun.

Biochim. Biophys. Res. Commun.

J. Biol. Chem.

J. Biol. Chem.

J. Biol. Chem.

Biochim. Biophys. Acta

J. Biol. Chem.

J. Biol. Chem.

J. Lipid Res.

J. Biol. Chem.

Biochim. Biophys. Acta

Biochim. Biophys. Acta

FEBS Lett.

Biochim. Biophys. Acta

Biochem. Biophys. Res. Commun.

Uber den Gang der amyloiden Degeneration

Arch. Pathol. Anat.

Heterogeneity of human serum amyloid A proteins

J. Exp. Med.

Identification of three isoform patterns of human serum amyloid A protein

Biochem. J.

Amino acid structures of multiple forms of amyloid-related serum protein SAA from a single individual

Biochemistry

Human serum amyloid A. Three hepatic mRNAs and the corresponding proteins in one person

J. Clin. Invest.

Isolation and charaterization of the amyloid-related apoprotein (SAA) from human high density lipoprotein

Amino acid sequence of amyloid-related apoprotein (apoSAA1) from human high-density lipoprotein

Biochemistry

The covalent structure of amyloid-related serum protein SAA from two patients with inflammatory disease

Hoppe-Seyler's Z. Physiol. Chem.

Isoproteins and an isoelectric focusing mutant of human apoprotein serum amyloid A

Electrophoresis

The primary structure of serum amyloid A protein in the rabbit: comparison with serum amyloid A proteins in other species

J. Lab. Clin. Med.

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Scand. J. Immunol.

Identification of a novel serum amyloid A protein in BALB/c mice

Biochem. J.

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Biochemistry

The amino acid sequence of serum amyloid A (SAA) protein in mink

Scand. J. Immunol.

Mink serum amyloid A protein, J. Biol. Chem., 265 (1990) 10049. 21 Sletten, K., Husebekk, A. and Husby, G., The primary structure of equine serum amyloid A (SAA) protein

Scand. J. Immunol.

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J. Lab. Clin. Med.

The complete amino acid sequence of bovine serum amyloid protein A (SAA) and of subspecies of the tissue-deposited amyloid fibril protein A

Scand. J. Immunol.

Analysis of the genomic and derived protein sequence of a novel human SAA amyloid A gene, SAA4

Scand. J. Immunol.

Human serum amyloid A (SAA): biosynthesis and postsynthetic processing PreeSAA and structural variants defined by complimentary DNA

Biochemistry

Review article
Serum amyloid A (SAA): an acute phase protein and apolipoprotein