Abstract
Yucheng (“oil-disease”) victims were Taiwanese people exposed to polychlorinated biphenyls (PCBs) and their heat-degradation products, mainly polychlorinated dibenzofurans (PCDFs), from the ingestion of contaminated rice oil in 1978–1979. Serial studies in Yucheng offspring born between 1978 and 1992 are summarized. Children of the exposed women were born with retarded growth, with dysmorphic physical findings, and, during development, with delayed cognitive development, increased otitis media, and more behavioral problems than unexposed children. Recently, examination of the reproductive system has suggested that prenatal exposure exerts late effects on semen parameters in young men after puberty. Results of the investigation in Yucheng children will provide important information about the human health effects and toxicology of PCB/PCDF exposure. Prenatal exposure to these environmental chemicals causes the fetus to be sensitive to the toxic effects of persistent organic pollutants.
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References
Brandeis DU, Lehmann D (1986) Event-related potentials of the brain and cognitive process: approaches and applications. Neuropsychologia 24:151–168
Chao WY, Hsu CC, Guo YL (1997) Increased prevalence of middle ear diseases in Yucheng children prenatally exposed to polychlorinated biphenyls and dibenzofurans. Arch Environ Health 52:257–262
Chen YJ, Hsu CC (1994) Effects of prenatal exposure to polychlorinated biphenyls on neurological function in children: a neuropsychologic and neurophysiologic study. Dev Med Child Neurol 36:312–320
Chen YCJ, Guo YL, Hsu CC, Rogan WJ (1992) Cognitive development of Yu-Cheng (‘oil-disease’) children prenatally exposed to heat-degraded PCBs. JAMA 268:3213–3218
Chen YC, Yu ML, Rogan WJ, Gladen BC, Hsu CC (1994) A six-year follow-up of behavioral and activity disorders in the Taiwan Yu-cheng children. Am J Public Health 284:415–421
Chen HL, Lee CC, Liao PC, Guo YL, Chen CH, Su HJ (2003) Associations between dietary intake and serum polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/F) levels in Taiwanese. Environ Res 91:172–178
del Rio-Gomez I, Marshall T, Tsai P, Shao YH, Guo YL (2002) Number of boys born to men exposed to polychlorinated biphenyls. Lancet 360:143–144
Faqi AS, Dalsenter PR, Merker HJ. Chahoud I (1998) Reproductive toxicity and tissue concentrations of low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin in male offspring rats exposed throughout pregnancy and lactation. Toxicol Appl Pharmacol 150:383–392
Fein GG, Jacobson JL, Jacobson SW, Schwartz PM, Dowler JK (1984) Prenatal exposure to polychlorinated biphenyls: effects on birth size and gestational age. J Pediatr 105:315–320
Finley WW, Faux SF, Hutcheson J, Amstutz L (1985) Long-latency event-related potentials in the evaluation of cognitive function in children. Neurology 35:323–327
Gladen BC, Taylor JS, Wu YC, Ragan NB, Rogan WJ, Hsu CC (1990) Dermatological findings in children exposed transplacentally to heat-degraded polychlorinated biphenyls in Taiwan. Br J Dermatol 122:799–808
Guo YL, Lai TJ, Ju SH, Chen YC, Hsu CC (1993) Sexual developments and biological findings in Yucheng children. Thirteenth International Symposium on Chlorinated Dioxins and Related Compounds, 24–28 September 1993, Vienna, Austria
Guo YL, Chen YC, Yu ML, Hsu CC (1994a) Early development of children prenatally exposed to heat-degraded PCBs born seven to twelve years after mothers’ poisoning. Chemosphere 29:2395–2404
Guo YL, Lin CJ, Yao WJ, Ryan JJ, Hsu CC (1994b) Musculoskeletal changes in children prenatally exposed to polychlorinated biphenyls and related compounds (Yu-Cheng children). J Toxicol Environ Health 41:83–93
Guo YL, Lambert GH, Hsu CC (1995a) Growth abnormalities in the population exposed in utero and early postnatally to polychlorinated biphenyls and dibenzofurans. Environ Health Perspect 103 [Suppl 6]:117–122
Guo YL, Lai TJ, Chen SJ, Hsu CC (1995b) Gender-related decrease in Raven’s Progressive Matrices scores in children prenatally exposed to polychlorinated biphenyls and related contaminants. Bull Environ Contam Toxicol 55:8–13
Guo YL, Ryan JJ, Lau BPY, Yu ML, Hsu CC (1997) Serum levels of PCB/PCDF congeners 14 years after accidental exposure to contaminated rice oil. Arch Environ Contam Toxicol 33:104–108
Guo YL, Hsu PC, Hsu CC, Lambert GH (2000) Sperm changes in humans prenatally exposed to polychlorinated biphenyls and dibenzofurans. Lancet 356:1240–1241
Guo YL, Yu ML, Hs CC (2003) The Yucheng rice oil poisoning incident. In: Schecter A, Gasiewicz TA (eds) Dioxins and health. Wiley, Hoboken, New Jersey, USA
Holcomb PJ, Ackerman PT, Dykman RA (1986) Auditory event-related potentials in attention and reading disabled boys. Int J Psychophysiol 3:263–273
Hsu CC, Su S, Shao SJ, Lin CC, Soong WT, Chang C (1978) Chinese child development inventory: a tentative normative data. Acta Paediatrica Sinica 19:142–152
Hsu MML, Mak CP, Hsu CC (1995) Follow-up of skin manifestations in Yu-Cheng children. Br J Dermatol 132:427–432
Hsu ST, Ma CI, Hsu SKH, Wu SS, Hsu NHM, Yeh CC, Wu SB (1985) Discovery and epidemiology of PCB poisoning in Taiwan: a four-year followup. Environ Health Perspect 59:5–10
Ju SH, Chen YJ, Chen YC, Hsu CC (1992) Follow-up study of growth and physical health of children born to mothers intoxicated by poly-chlorinated biphenyls (PCBs). Presented at the Annual Meeting of the American Pediatric Society and Society for Pediatric Research, May 1992, Baltimore, USA
Kashimoto T, Miyata H, Fukushima S, Kunita N, Ohi G, Tung TC (1985) PCBs, PCQs and PCDFs on blood of Yusho and Yu-Cheng patients. Environ Health Prospect 59:73–78
Kimbrough RD (1985) Laboratory and human studies on polychlorinated biphenyls (PCBs) and related compounds. Environ Health Perspect 59:99–106
Kodama H, Ota H (1980) Transfer of polychlorinated biphenyls to infants from their mothers. Arch Environ Health 35:95–100
Lai TJ, Liu XC, Guo YL, Guo NW, Yu ML, Hsu CC, Rogan WJ (2002) A cohort study of behavioral problems and intelligence in children with high prenatal polychlorinated biphenyls exposure. Arch Gen Psychiatry 59:1061–1066
Lambert GH, Schoeller DA, Kotake AN, Flores C, Hay D (1986) The effect of age, gender, and sexual maturation on the caffeine breath test. Dev Pharmacol Ther 9:375–388
Lan CF, Chen PH, Shieh LL, Chen YH (1981) An epidemiological study on polychlorinated biphenyls poisoning in Taichung area (in Chinese with an English summary). Clin Med (Taipei) 7: 96–100
Lan SJ, Yen YY, Yang CH, Yang CY, Chen ER (1987) A study of the birth weight of transplacental Yu-Cheng babies (in Chinese with an English summary). Kaohsiung J Med Sci 3:273–282
Lione A (1988) Polychlorinated biphenyls and reproduction. Reprod Toxicol 2:83–89
Lü YC, Wong PN (1984) Dermatological, medical, and laboratory findings of patients in Taiwan and their treatments. Am J Ind Med 5:81–115
Masuda Y, Kagawa R, Kuroki H, Kuratsune M, Yoshimura T, Taki I, Kusuda M, Yamashida F, Hayashi M (1978) Transfer of polychlorinated biphenyls from mothers to foetuses and infants. Food Cosmet Toxicol 16:543–546
Masuda Y, Kuroki H, Haraguchi K, Nagayama J (1986) PCDFs and related compounds in humans from Yusho and Yu-Cheng incidents. Chemosphere 15:1621–1628
Platonow NS, Liptrap RM, Geissinger HD (1972) The distribution and excretion of polychlorinated biphenyls (Aroclor 1254) and their effect on urinary gonadal steroid levels in the boar. Bull Environ Contam Toxicol 7:358–365
Robaey P, Breton F, Dugas M, Renault B (1992) An event-related potential study of controlled and autonomic processes in 6–8 years old boys with attention deficit hyperactivity disorder. Electroencephalogr Clin Neurophysiol 82:330–340
Rogan WJ, Gladen BC, Hung KL, Koong SL, Shih LY, Taylor JS, Wu YC, Yang D, Ragan NB, Hsu CC (1988) Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan. Science 241:334–336
Rogan WJ, Gladen BC, Guo YL, Yu ML, Hsu CC (1999) Sex ratio after exposure to dioxin-like chemicals in Taiwan. Lancet 353:206–207
Rutter M, Tizard J, Whitmore K (1970) A children’s behavior questionnaire for completion by parents, appendix 6. In: Education, health, and behavior: psychological and medical study of childhood development. Wiley, New York, pp 412–421
Ryan JJ, Hsu CC, Boyle MJ, Guo YL (1994) Blood serum levels of PCDFs and PCBs in Yu-Cheng children perinatally exposed to a toxic rice oil. Chemosphere 29:1263–1278
Safe S (1987) Determination of 2,3,7,8,-TCDD toxic equivalent factors (TEFs): support for the use of the in vitro AHH induction assay. Chemosphere 16:791–802
Safe S, Astroff B, Harris M, Zacharewski T, Dickerson R, Romkes M, Biegel L (1991) 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related compounds as antioestrogens: characterization and mechanism of action. Pharmacol Toxicol 69:400–409
Schwartz PM, Jacobson SW, Fein G, Jacobson JL, Price HA (1983) Lake Michigan fish consumption as a source of polychlorinated biphenyls in human cord serum, maternal serum and milk. Am J Public Health 73:293–296
Steele G, Stehr-Green P, Welty E (1986) Estimates of the biological half-life of polychlorinated biphenyls in human serum. N Engl J Med 314:926–927
Sutton S, Braren M, Zubin J, John ER (1965) Evoked potential correlates of stimulus uncertainty. Science 150:187–188
Tilson HA, Jacobson JL, Rogan WJ (1990) Polychlorinated biphenyls and the developing nervous system: cross-species comparisons. Neurotoxicol Teratol 12:239–248
Wang SLJ, Chen TT, Hsu JF, Hsu CC, Chang L, Ryan JJ, Guo YL, Lambert GH (2003) Neonatal and childhood teeth in relation to in utero exposure to PCBs/PCDFs—the observations from Yucheng children in Taiwan. Environ Res 93:131–137
Wong CK, Chen CJ, Cheng PC, Chen PHS (1982) Mucocutaneous manifestations of polychlorinated biphenyls (PCB) poisoning: a study of 122 cases in Taiwan. Br J Dermatol 107:317–323
Werry JS (1968) Developmental hyperactivity. Pediatr Clin North Am 15:581–599
Widholm JJ, Clarkson GB, Strupp BJ, Crofton KM, Seegal RF, Schantz SL (2001) Spatial reversal learning in Aroclor 1254-exposed rats: sex-specific deficits in associative ability and inhibitory control. Toxicol Appl Pharmacol 174:188–198
Yu ML, Hsu CC, Gladen BC, Rogan WJ (1991) In utero PCB/PCDF exposure: relation of developmental delay to dysmorphology and dose. Neurotoxicol Teratol 13:195–202
Yu ML, Guo YL, Hsu CC, Rogan WJ (2000) Menstruation and reproduction in women with polychlorinated biphenyl (PCB) poisoning: long-term follow-up interviews of the women from the Taiwan Yucheng cohort. Int J Epidemiol 29:672–677
Acknowledgement
The investigation of Yucheng cohort was supported by grant nos. NSC91-3112-B-006-006 from the National Science Council and NHRI-EX91-9025PL from National Health Research Institute.
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Guo, Y.L., Lambert, G.H., Hsu, CC. et al. Yucheng: health effects of prenatal exposure to polychlorinated biphenyls and dibenzofurans. Int Arch Occup Environ Health 77, 153–158 (2004). https://doi.org/10.1007/s00420-003-0487-9
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DOI: https://doi.org/10.1007/s00420-003-0487-9