Abstract
A comprehensive case-control study was conducted in an Italian region in order to compare the influence of family history of cardiovascular events, socioeconomic factors, social networks, and their joint associations with major risk factors, on the risk, of myocardial infarction (MI), unstable angina (UA) and ischemic stroke (IS). A total of 513 patients with MI, 178 with UA, 237 with IS, and 928 hospitalised controls were recruited. The odds ratio (OR) of MI for two or more relatives with a positive history of MI was 3.6 (95% CI: 1.8–7.3). Family history of MI was predictive for UA (OR = 5.8; 95% CI: 1.2–28.7), but not for IS. A family history of stroke was more associated with the risk of MI than of IS. After adjustment for known risk factors, the OR of MI for more educated people was 2.1 (1.3–3.6) compared with less-educated people. Large family size seemed to be protective for MI. The effect of major risk factors on MI ranged from additive (diabetes) to multiplicative jointly with high education and family history of MI. A family history of stroke increased IS risk threefold jointly with smoking and hyperlipidemia, and eightfold with diabetes. Besides a family history of MI and IS, in this community a higher educational status seems to better identify groups at increased risk of MI. The joint associations have important preventive implications since by identifying high-risk individuals (for MI and IS) a more careful assessment and control of risk factors amenable to intervention may be performed.
Participating clinical centres: Atessa: L. Massa, M. Puglfese (Medicina); Avezzano: G. Rabftti, G. Del Bove Orlandi (Medicina); E. Laconi F. Tiburzi (UTIC); Casoli: M. Padula (Medicina); Castel di Sangro: P Caracciolo, V Di Tomasso (Medicina); Chieti: S. Sensi, G. Bitti (Medicina); D. Gambi, S. Viola (Neurologia); A. Rossi, C. Ciglia (UTIC); Gissi: M. Colaneri (Medicina); Giulianova: N. Di Giacinto (UTIC); Guardiagrele: F. Liberatoscioli, M. De Luca (UTIC); Lanciano: V Montagano, B. Di Martino (Neurologia); A. Ottaviano, G. Mastrogiuseppe (UTIC); L'Aquila: E. Marsili, P. Marsili (UTIC); Ortona: G. Giambuzzi (Medicina); Penne: O. Pesa (Medicina); D. Di Gregorio, G. Di Paolo (UTIC); Pescara: B. Carosella, A. Mancini (Medicina); G. Liberti, G. Acerbi (Neurochirurgia); E. D'Annunzio, C. Stoduto (UTIC); Pescina: A. Biocca, G. Barbati (Medicina); Popoli: D. Artese, M. Di Cioccio (Medicina); A. Mobili (UTIC); S. Omero: G. Triozzi, E. Di Biase (Medicina); Sulmona: E. Conti, G. Bonasia (UTIC); Tagliacozzo: G. Appodia (Medicina); Teramo: L. Piccioni (UTIC); Tocco Casauria: M. Zappacosta (Medicina); Vasto: Del Fomo (Medicina); D-Antonini, M. Cipulli (Neurologia); G. Di Marco, E. Bottari (UTIC). UTIC: Unità di Terapia Intensiva Coronarica.
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Alberts MJ. Genetic aspects of cerebrovascular disease. Stroke 1991; 22: 276–280.
Barrett-Connor E, Khaw K-T. Family history of heart attack as an independent predictor of death due to cardiovascular disease. Circulation 1984; 69: 1065–1069.
Brass LM, Isaacsohn JL, Merikangas KR, Robinette CD. A study of twins and stroke. Stroke 1992; 23: 221–223.
Brass LM, Shaker LA. Family history in patients with transient ischemic attacks. Stroke 1991; 22: 837–841.
Breslow NE, Day NE. Statistical methods in cancer research. Vol. 1. The analysis of case-control studies. Lyon: IARC Scientific Publications, No. 33, 1980.
Colditz GA, Rimm EB, Giovannucci E, Stampfer MJ, Rosner B, Willett WC. A prospective study of parental history of myocardial infarction and coronary artery disease in men. Am J Cardiol 1991; 67: 933–938.
Colditz GA, Stampfer MJ, Willett WC, t al. A prospective study of parental history of myocardial infarction and coronary heart disease in women. Am J Epidemiol 1986; 123: 48–58.
Corrao G, di Orio F. Mortality per causa e Unità Locale Socio-Sanitaria in Abruzzo 1980–1983 [Mortality by cause and Local Health District in Abruzzo]. Roma: Euroma, Editrice Universitaria di Roma La Goliardica, 1987: 171–199.
Cortellaro M, Boschetti C, Cofrancesco E, et al. The PLAT study: hemostatic function in relation to atherothrombotic ischemic events in vascular disease patients. Principal Results. Arterioscler Tromb 1992; 12:1063–1070.
Demirovic J, Epstein FH. Summary of workshop on psychosocial factors in coronary heart disease: measurement, evaluation, and intervention. Eur Heart J 1988; 9: 687–689.
Diaz JF, Hachinski VC, Pederson LL, Donald A. Aggregation of multiple risk factors for stroke in siblings of patients with brain infarction and transient ischemic attacks. Stroke 1986; 17: 1239–1242.
Farchi G, Fidanza F, Mariotti S, Menotti A. Alcohol and mortality in the Italian rural cohorts of the Seven Countries Study. Int J Epidemiol 1992; 21: 74–82.
Herman B, Schmitz PIM, Leyten ACM, et al. Multivariate logistic analysis of risk factors for stroke in Tilburg, the Netherlands. Am J Epidemiol 1983; 118: 514–525.
Hopkins PN, Williams RR. Human genetics and coronary heart disease: a public health perspective. Annu Rev Nutr 1989; 9: 303–345.
ISTAT. Indagine statistica sulle condizioni di salute della popolazione e sul ricorso ai servizi sanitari novembre 1983 [Survey on population health status and health services access]. Roma: ISTAT, 1986.
ISTAT. Indagine statistica sulle condizioni di salute della popolazione e sul ricorso ai servizi sanitari novembre 1986–aprile 1987 [Survey on population health status and health services access]. Roma: ISTAT, 1991.
Istituto Nazionale di Statistica. Le regioni in cifre [Regions in figures]. Roma: ISTAT, 1992: 37.
Johnson JV, Hall EM. Job strain, work place social support, and cardiovascular disease: a cross-sectional study of a random sample of the Swedish working population. Am J Public Health 1988; 78: 1336–1342.
Khaw KT, Barrett-Connor E. Family history of stroke as an independent predictor Of ischemic heart disease in men and stroke in women. Am J Epidemiol 1986; 123: 59–66.
Marmot MG, Kogevinas M, Elston MA. Social/ economic status and disease. Annu Rev Public Health 1987; 8: 111–135.
Marmot M. Socioeconomic determinants of CHD mortality. Int J Epidemiol 1989; 18(suppl 1): S196–202.
Myers RH, Kiely DK, Adrienne Cupples LA, Kannel WB. Parental history is an independent risk factor for coronary hart disease: The Framingham Study. Am Heart J 1990; 120: 963–969.
Roncaglioni MC, Santoro L, D'Avanzo B, et al. Role of family history in patients with myocardial infarction. An Italian case-control study. Circulation 1992; 85: 2065–2072.
Rothman KJ. Modern epidemiology. Boston/Toronto: Little, Brown and Company, 1986.
Ruberman W, Weinblatt E, Goldberg JD, Chaudhary BS. Psychosocial influences on mortality after myocardial infarction. N Engl J Med 1984; 311: 552–559.
SAS Institute Inc. SAS/STAT (1989): User's Guide. Version 6, 4th ed, Vol 1–2. Cary, NC: SAS Institute Inc.
Shaper AG, Phillips AN, Pocock SJ, et al. Risk factors for stroke in middle ages British men. Br Med J 1991; 302: 1111–1115.
Sholtz RI, Rosenman RH, Brand RJ. The relationship of reported parental history to the incidence of coronary heart disease in the Western Collaborative Group Study. Am J Epidemiol 1975; 102: 350–356.
Smith PG, Day NE. The design of case-control studies: the influence of confounding and interaction effects. Int J Epidemiol 1984; 13: 356–365.
Tenconi MT, Romanelli C, Gigli F, et al. The relationship between education and risk factors for coronary heart disease. Eur J Epidemiol 1992; 8: 763–769.
Welin L, Svdrdsudd K, Wilhelmsen L, Larsson B, Tibblin G. Analysis of risk factors for stroke in a cohort of men born in 1913. N Engl J Med 1987; 317: 521–526.
World Health Organization. Cerebrovascular diseases — prevention, treatment and rehabilitation. Technical Report Series No. 469. Geneva: WHO, 1971.
World Health Organization. Cerebrovascular diseases — prevention, treatment and rehabilitation. Technical Report Series No. 469. Geneva: WHO, 1971.
World Health Organization. Ischemic heart disease registers: report of the Fifth Working Group. Copenhagen: WHO, 1971.
Zimmemann-Tansella C, Donini S, Galvan U, et al. Social support, adversities and emotional distress in an Italian community sample. J Clin Epidemiol 1993; 46: 65–75.
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PROGETTO 3A (Alimentazione - Aterosclerosi - Abruzzo). Scientific advisory board: F. Capani, F. D'Agostino G. de Gaetano & F. Stante
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Vitullo, F., Marchioli, R., Di Mascio, R. et al. Family history and socioeconomic factors as predictors of myocardial infarction, unstable angina and stroke in an Italian population. Eur J Epidemiol 12, 177–185 (1996). https://doi.org/10.1007/BF00145504
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DOI: https://doi.org/10.1007/BF00145504