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Leukemia, lymphoma, and multiple myeloma following selected medical conditions

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The role of selected prior medical conditions in the etiology of hematopoietic malignancies was examined in a case-control study of members of two regional branches of the Kaiser Permanente Medical Care Program (USA). Past history of chronic infectious, autoimmune, allergic, and musculoskeletal disorders was abstracted from medical records for leukemia (n = 299), non-Hodgkin's lymphoma (NHL, n = 100), and multiple myeloma (n = 175) cases and matched controls (n = 787). Little difference was found between cases and controls for most of the chronic conditions evaluated, including sinusitis, carbuncles, urinary tract infections, pelvic infections, herpes zoster, asthma, rheumatoid arthritis, psoriasis, bursitis, and gout. Only three statistically significant elevated risks were found, i.e., with combined disc disease myeloma among patients with prior eczema and disk and other musculoskeletal conditions, and NHL following tuberculosis. Only two of these associations showed consistent patterns by sex and geographic region (myeloma with eczema and with musculoskeletal conditions). While prior history of eczema and musculoskeletal conditions may slightly increase risk of myeloma, this study provided little if any support for an association of chronic infectious, autoimmune, allergic, and musculoskeletal conditions with subsequent occurrence of the leukemias or NHL. Additionally, these data did not support a role for chronic antigenic stimulation, as defined in previous epidemiologic studies, in the etiology of hematopoietic malignancies.

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References

  1. Linet MS. The Leukemias: Epidemiologic Aspects. New York: Oxford University Press, 1985.

    Google Scholar 

  2. Greene MH. Non-Hodgkin's lymphoma and mycosis fungoides. In: Schottenfeld D, Fraumeni JFJr, eds. Cancer Epidemiology and Prevention. Philadelpia, PA: W.B. Saunders, 1982; 754–78.

    Google Scholar 

  3. Riedel DA, Pottern LM. The epidemiology of multiple myeloma. In: Barlogie B, ed. Hematology/Oncology Clinics of North America: Multiple Myeloma. Philadelphia, PA: W.B. Saunders Company, 1992: 225–47.

    Google Scholar 

  4. Talal N, Bunim JJ. The development of malignant lymphoma in the course of Sjögren's syndrome. Am J Med 1964; 36: 529–40.

    Google Scholar 

  5. Lea AJ. An association between the rheumatic diseases and the reticuloses. Ann Rheum Dis 1964; 23: 480–4.

    Google Scholar 

  6. Goldenberg GJ, Paraskevas F, Israels LG. The association of rheumatoid arthritis with plasma cell and lymphocytic neoplasms. Arthritis Rheum 1969; 12: 569–76.

    Google Scholar 

  7. Isobe T, Osserman EF. Pathologic conditions associated with plasma cell dyscrasias: a study of 806 cases. Ann NY Acad Sci 1971; 190: 507–18.

    Google Scholar 

  8. McIntire KR, Princher GL. Prolonged adjuvant stimulation in germ-free BALB/c mice: Development of plasma cell neoplasia. Immunology 1969: 17: 481–7.

    Google Scholar 

  9. Porter DD, Larsen AE, Porter HG. Aleutian disease of mink. Adv Immunol 1980; 29: 261–86.

    Google Scholar 

  10. Lee JC, Ihle JN. Chronic immune stimulation is required for Moloney leukaemia virus-induced lymphomas. Nature 1982; 289: 407–9.

    Google Scholar 

  11. Linet MS, McCaffrey LD, Humphrey RL, et al. Chronic lymphocytic leukemia and acquired disorders affecting the immune system: a case-control study. JNCI 1986; 77: 371–8.

    Google Scholar 

  12. Tielsch JM, Linet MS, Szklo M. Acquired disorders affecting the immune system and non-Hodgkin's lymphoma. Prev Med 1987; 16: 96–106.

    Google Scholar 

  13. Koepsell TD, Daling JR, Weiss NS, et al. Antigenic stimulation and the occurrence of multiple myeloma. Am J Epidemiol 1987; 126: 1051–62.

    Google Scholar 

  14. Isomaki HA, Hakulinen T, Joutsenlahti U. Excess risk of lymphomas, leukemia and myeloma in patients with rheumatoid arthritis. J Chronic Dis 1978; 31: 391–6.

    Google Scholar 

  15. Prior P, Symmons DPM, Hawkins CP, et al. Cancer morbidity in rheumatoid arthritis. Ann Rheum Dis 1984; 43: 128–31.

    Google Scholar 

  16. Pearce N, Porter M. Association of non-Hodgkin's lymphoma with rheumatoid arthritis. Am J Med 1986; 81: 747–8.

    Google Scholar 

  17. Pearce NE, Smith AH, Howard JK, Sheppard RA, Giles HJ, Teague CA. Case-control study of multiple myeloma and farming. Br J Cancer 1986; 54: 493–500.

    Google Scholar 

  18. Gramenzi A, Buttino I, D'Avanzo B, Negri E, Franceschi S, La Vecchia C. Medical history and the risk of multiple myeloma. Br J Cancer 1991; 63: 769–72.

    Google Scholar 

  19. Gallagher RP, Spinelli JJ, Ellwood JM, Skippen DH. Allergies and agricultural exposure as risk factor for multiple myeloma. Br J Cancer 1983; 48: 853–7.

    Google Scholar 

  20. Franceschi S, Serraino D, Bidoli E, et al. The epidemiology of non-Hodgkin's lymphoma in the north-east of Italy: a hospital-based case-control study. Leuk Res 1989; 13: 465–72.

    Google Scholar 

  21. Rosenblatt KA, Koepsell TD, Daling JR, et al. Antigenic stimulation and the occurrence of chronic lymphocytic leukaemia. Am J Epidemiol 1991; 134: 22–8.

    Google Scholar 

  22. Cartwright RA, Bernard SM, Bird CC, et al. Chronic lymphocytic leukemia: case-control epidemiological study in Yorkshire. Br J Cancer 1987; 56: 79–82.

    Google Scholar 

  23. Cartwright RA, McKinney PA, O'Brien C, et al. Non-Hodgkin's lymphoma: case-control epidemiological study in Yorkshire. Leuk Res 1988; 12: 81–8.

    Google Scholar 

  24. Gibson R, Graham S, Lilienfeld A, Schumann L, Levin M, Swanson M. Epidemiology of diseases in adult males with leukemia. JNCI 1976; 56: 891–8.

    Google Scholar 

  25. McCormick DP, Ammann AJ, Ishizaka K, Miller DG, Hong R. A study of allergy in patients with malignant lymphoma and chronic lymphocytic leukemia. Cancer 1971; 27: 93–9.

    Google Scholar 

  26. Vena JE, Bona JR, Byers TE, Middleton EJr, Swanson MK, Graham S. Allergy-related disease and cancer. An inverse association. Am J Epidemiol 1985; 122: 66–74.

    Google Scholar 

  27. Linet MS, Harlow SD, McLaughlin JK. A case-control study of multiple myeloma in Whites: chronic antigenic stimulation, occupation and drug use. Cancer Res 1987; 47: 2978–81.

    Google Scholar 

  28. Cohen HJ, Bernstein RJ, Grufferman S. Role of immune stimulation in the etiology of multiple myeloma: a case-control study. Am J Hematol 1987; 24: 119–26.

    Google Scholar 

  29. Boice JDJr, Morin MM, Glass AG, et al. Diagnostic X-ray procedures and risk of leukemia, lymphoma, and multiple myeloma. JAMA 1991; 265: 1290–4.

    Google Scholar 

  30. Friedman GD. Phenylbutazone, musculoskeletal disease, and leukemia. J Chronic Dis 1982; 35: 233–43.

    Google Scholar 

  31. Friedman GD. Multiple myeloma: relation to propoxyphene and other drugs, radiation, and occupation. Int J Epidemiol 1986; 15: 424–6.

    Google Scholar 

  32. Breslow NB, Day NE, Statistical Methods in Cancer Research. Lyon, France: International Agency for Research on Cancer, 1980; IARC Sci. Pub. No. 32: 1162–89.

    Google Scholar 

  33. Thomas DG. Exact and asymptotic methods for the combination of 2×2 tables. Comput Biomed Res 1975;8: 423–46.

    Google Scholar 

  34. Lubin JH. A computer program for the analysis of matched case-control studies. Comput Biomed Res 1981; 14: 138–43.

    Google Scholar 

  35. Cuzick J, DeStavola B. Multiple myeloma—a case control study. Br J Cancer 1988; 57: 516–20.

    Google Scholar 

  36. Davis FG, Boice JDJr, Hrubac Z, Monson RR. Cancer mortality in a radiation-exposed cohort of Massachusetts tuberculosis patients. Cancer Res 1989; 49: 6130–6.

    Google Scholar 

  37. Monson RR, Hall AP. Mortality among arthritics. J Chronic Dis 1976; 29: 459–67.

    Google Scholar 

  38. Hakulinen T, Isomaki H, Knekt P. Rheumatoid arthritis and cancer studies based on linking nationwide registries in Finland. Am J Med 1985; 78 (Suppl 1A): 29–32.

    Google Scholar 

  39. Boffetta P, Stellman SD, Garfinkel L. A case-control study of multiple mycloma nested in the American Cancer Society prospective study. Int J Cancer 1989; 43: 554–9.

    Google Scholar 

  40. McKinney PA, Alexander FE, Roberts BE, O'Brien C, Bird CC, Cartwright RA. Yorkshire case-control study of leukemias and lymphomas: parallel multivariate analyses of seven disease categories. Leuk Lymph 1990; 2: 67–80.

    Google Scholar 

  41. Severson RK, Davis S, Thomas DB, Stevens RG, Heuser L, Sever LE. Acute myelocytic leukemia and prior allergies. J Clin Epidemiol 1989; 42: 995–1001.

    Google Scholar 

  42. Pottern LM, Linet MS, Blair A, et al. Familial cancers associated with subtypes of leukemia and non-Hodgkin's lymphoma. Leuk Res 1991; 15: 305–14.

    Google Scholar 

  43. Linet MS, Harlow SD, McLaughlin JK, McCaffrey LD. A comparison of interview data and medical records for previous medical conditions and surgery. J Clin Epidemiol 1989; 42: 1207–13.

    Google Scholar 

  44. Harlow SD, Linet MS. Agreement between questionnaire data and medical records: The evidence for accuracy of recall. Am J Epidemiol 1989; 129: 233–48.

    Google Scholar 

  45. Hartge P, Devesa S. Quantification of the impact of known risk factors on time trends in NHL ineidence. Cancer Research, 1992 (in press).

  46. Kyle RA. Case definition: issues related to monoclonal gammopathies and multiple myeloma: In: Obrams GI, Potter M, eds. Epidemiology and Biology of Multiple Myeloma. Berlin: Springer-Verlag, 1991: 75–81.

    Google Scholar 

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Authors
  1. Michele Morin Doody
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  2. Martha S. Linet
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  3. Andrew G. Glass
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  4. Gary D. Friedman
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  5. Linda M. Pottern
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  6. John D. Boice Jr
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  7. Joseph F. Fraumeni Jr
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Additional information

Ms Doody and Drs Linet, Pottern, Boice, and Fraumeni are with the Epidemiology and Biostatistics Program, National Cancer Institute. Dr Glass is with the Kaiser Permanente Medical Care Program, Northwest Region, Portland, Oregon, USA. Dr Friedman is with the Kaiser Permanente Medical Care Program, Northern California Region, Oakland, California, USA. Address correspondence to Ms Doody, Radiation Epidemiology Branch, National Cancer Institute, Executive Plaza North, Room 408, Bethesda, MD 20892, USA. This research was supported in part by National Cancer Institute contracts NO1-CP-01047, NO1-CP-01054, NO1-CP-11009, NO1-CP-11037, NO1-CP-31035, and NO1-CP-61006.

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Doody, M.M., Linet, M.S., Glass, A.G. et al. Leukemia, lymphoma, and multiple myeloma following selected medical conditions. Cancer Causes Control 3, 449–456 (1992). https://doi.org/10.1007/BF00051358

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  • DOI: https://doi.org/10.1007/BF00051358

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