Probability of regions of practical equivalence for three broad life course models based on Chumbley et al26
| Signatures | Accumulation | Sensitive | Critical |
| CVD (PC1) | 0.02 | 0.80 | 0.18 |
| Lupus (PC5) | 0.01 | 0.66 | 0.33 |
| Colorectal (PC3) | 0.03 | 0.90 | 0.08 |
| RA (PC1) | 0.00 | 0.62 | 0.38 |
| RA (PC4) | 0.01 | 0.61 | 0.38 |
| RA (PC5) | 0.03 | 0.83 | 0.14 |
| Asthma (PC2) | 0.01 | 0.72 | 0.26 |
| Asthma (PC3) | 0.01 | 0.71 | 0.28 |
| Diabetes (PC3) | 0.01 | 0.66 | 0.34 |
| Diabetes (PC5) | 0.00 | 0.45 | 0.54 |
| Inflammation (PC2) | 0.00 | 0.43 | 0.57 |
| Inflammation (PC3) | 0.02 | 0.75 | 0.23 |
| Inflammation (PC4) | 0.01 | 0.75 | 0.24 |
| Alzheimer (PC2) | 0.01 | 0.69 | 0.30 |
| Alzheimer (PC6) | 0.01 | 0.86 | 0.13 |
| Ageing (PC2) | 0.00 | 0.49 | 0.51 |
| Ageing (PC4) | 0.00 | 0.71 | 0.28 |
CVD, cardiovascular disease; PC, principal component; RA, rheumatoid arthritis.