Decomposition of the weighted total effects in average direct effect (ADE) and average causal mediated effects (ACME) with credible interval for each of the PCs
| Signatures | ADE | ACME | (Credible interval) | Proportion mediated |
| CVD (PC1) | 0.016 | 0.008 | (0.005, 0.012) | 0.331 |
| Lupus (PC5) | 0.015 | 0.016 | (0.012, 0.021) | 0.518 |
| Colorectal (PC3) | 0.033 | 0.009 | (0.005, 0.013) | 0.208 |
| RA (PC1) | 0.022 | 0.009 | (0.005, 0.012) | 0.282 |
| RA (PC4) | 0.024 | 0.005 | (0.003, 0.008) | 0.166 |
| RA (PC5) | 0.022 | 0.006 | (0.003, 0.010) | 0.219 |
| Asthma (PC2) | 0.034 | 0.006 | (0.003, 0.009) | 0.143 |
| Asthma (PC3) | 0.025 | 0.002 | (−0.001, 0.005) | 0.061 |
| Diabetes (PC3) | 0.011 | 0.006 | (0.003, 0.009) | 0.343 |
| Diabetes (PC5) | 0.015 | 0.009 | (0.006, 0.013) | 0.383 |
| Inflammation (PC2) | −0.021 | −0.005 | (−0.008, –0.002) | 0.185 |
| Inflammation (PC3) | 0.015 | 0.006 | (0.004, 0.009) | 0.296 |
| Inflammation (PC4) | 0.030 | 0.014 | (0.010, 0.018) | 0.311 |
| Alzheimer (PC2) | −0.028 | 0.000 | (−0.003, 0.002) | 0.012 |
| Alzheimer (PC6) | 0.022 | 0.009 | (0.006, 0.013) | 0.291 |
| Ageing (PC2) | 0.027 | 0.003 | (0.001, 0.006) | 0.110 |
| Ageing (PC4) | 0.039 | 0.012 | (0.008, 0.016) | 0.231 |
CVD, cardiovascular disease; PC, principal component; RA, rheumatoid arthritis.