Table 4

Decline in HRs of mood (affective) disorders* in the study population of people born in Sweden from 1 January 1973 to 31 December 1995† after adjustment

No parental AUDParental AUD‡
≥1 parentFatherMotherFather and mother
Number (% of total study population)2 321 756
(95.9)
99 723
(4.1)
76 476
(3.2)
28 533
(1.2)
5286
(0.2)
Crude HR (95% CI)1.002.32 (2.26 to 2.39)2.21 (2.14 to 2.28)2.83 (2.71 to 2.96)3.91 (3.60 to 4.25)
Model 1: adjusted HR (95% CI)§1.002.05 (1.99 to 2.10)1.91 (1.85 to 1.97)2.48 (2.37 to 2.60)3.06 (2.81 to 3.33)
 Explained difference (%)20.524.819.129.2
Model 2: adjusted HR (95% CI)¶1.001.67 (1.63 to 1.72)1.61 (1.56 to 1.66)1.82 (1.74 to 1.91)2.07 (1.90 to 2.26)
 Explained difference (%)36.233.044.648.1
Total explained difference (%)49.249.655.263.2
  • *Mood disorders were defined with ICD-10 codes and their historical equivalents: ICD-10 codes F30–F39, mood (affective) disorders. See online supplemental table 2 for the ICD-9 and ICD-8 codes used in the study.

  • †Only live births were included.

  • ‡Parents were diagnosed with AUD either before the child was born or until the child turned 18 (diagnosis received between 1 January 1973 and 31 December 2018).

  • §Adjusted for sex, parents’ highest level of education and death of one or both parents before the child turned 18 years.

  • ¶Adjusted for sex, parents’ highest level of education, death of one or both parents before the child turned 18 years and parental diagnosis of the disorder analysed.

  • AUD, alcohol use disorder; ICD, International Statistical Classification of Diseases and Related Health Problems.