BC | |||||
FH | OR* | 95% CI | Comorbidity patterns | OR* | 95% CI |
No | 1 | – | Healthy | 1 | – |
Yes | 2.49 | (2.01–3.10) | Metabolic disorders | 1.23 | (1.02–1.49) |
Hysterectomy, uterine fibroids and bilateral ovariectomy | 0.77 | (0.64–0.94) | |||
Breast diseases | 1.89 | (1.23–2.90) | |||
Ovarian cysts and unilateral ovariectomy | 0.76 | (0.48–1.22) |
Comorbidity patterns | ||||||||
Metabolic disorders | Hysterectomy, uterine fibroids and bilateral ovariectomy | Breast diseases | Ovarian cysts and unilateral ovariectomy | |||||
FH | OR† | 95% CI | OR† | 95% CI | OR† | 95% CI | OR† | 95% CI |
No | 1 | – | 1 | – | 1 | – | 1 | – |
Yes | 1.32 | (0.91 to 1.91) | 1.29 | (0.92 to 1.79) | 4.09 | (2.48 to 6.74) | 1.29 | (0.54 to 3.07) |
ORs and related 95% CI of BC according to FH of BC and comorbidity patterns, and ORs and related 95% CIs of comorbidity pattern according to FH. ORs and related 95% CIs of comorbidity patterns according to FH. Italy and Switzerland, 1991–2008.
*Models adjusted for age, centre, education, menopausal status, parity, ever OC use and ever HRT use, smoking habits and alcohol drinking.
†Multinomial logistic model with ‘healthy’ pattern set as reference.
BC, breast cancer; FH, family history.